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Application of Advances in Synthetic Biology to Modular Megasynthase Design and Scalable Combinatorial Biosynthesis
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| 자료유형 | E-Book |
|---|---|
| 개인저자 | Grau, William Clifford. |
| 단체저자명 | University of Colorado at Boulder. Chemistry. |
| 서명/저자사항 | Application of Advances in Synthetic Biology to Modular Megasynthase Design and Scalable Combinatorial Biosynthesis. |
| 발행사항 | [S.l.] : University of Colorado at Boulder., 2018 |
| 발행사항 | Ann Arbor : ProQuest Dissertations & Theses, 2018 |
| 형태사항 | 188 p. |
| 소장본 주기 | School code: 0051. |
| ISBN | 9780438383920 |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 80-02(E), Section: B.
Adviser: Ryan T. Gill. |
| 요약 | The diversity in structure and biological activity of natural products has long captured the imagination of chemists and molecular biologists alike. Natural products are synthesized by elaborate secondary metabolic pathways or enzymes. For examp |
| 요약 | Prior efforts to rationally design modular megasynthases have demonstrated some success but combinatorial forward engineering remains unfulfilled. The rise of synthetic biology has presented new capabilities to resolve the underlying deficiencie |
| 요약 | Herein, we present a precise and scalable synthetic biology approach to combinatorial biosynthesis built on improved abstraction of modular megasynthases into 'parts'. The approach begins with bottom-up design of a chimeric modular megasynthase |
| 요약 | To demonstrate this approach, we first targeted the production of a triketide lactone food and fragrance ingredient, d-hexalactone. A retrosynthetic analysis identified catalytic domains, linkers, and substrates required for d-hexalactone biosyn |
| 일반주제명 | Chemistry. Bioengineering. Chemical engineering. |
| 언어 | 영어 |
| 기본자료 저록 | Dissertation Abstracts International80-02B(E). Dissertation Abstract International |
| 대출바로가기 | http://www.riss.kr/pdu/ddodLink.do?id=T14999991 |
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| No. | 등록번호 | 청구기호 | 소장처 | 도서상태 | 반납예정일 | 예약 | 서비스 | 매체정보 |
|---|---|---|---|---|---|---|---|---|
| 1 | WE00024726 | DP 540 | 가야대학교/전자책서버(컴퓨터서버)/ | 대출불가(별치) |
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