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Inteins as Biomolecular Switches: Applications in Drug Discovery, Protein Purification, and Stress Response

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자료유형	E-Book
개인저자	Pearson, C. Seth.
단체저자명	Rensselaer Polytechnic Institute. Chemical Engineering.
서명/저자사항	Inteins as Biomolecular Switches: Applications in Drug Discovery, Protein Purification, and Stress Response.
발행사항	[S.l.] : Rensselaer Polytechnic Institute., 2018
발행사항	Ann Arbor : ProQuest Dissertations & Theses, 2018
형태사항	102 p.
소장본 주기	School code: 0185.
ISBN	9780438206229
일반주기	Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B. Advisers: Georges Belfort
요약	Inteins are protein elements that autocatalytically excise themselves from a host protein in a process called protein splicing. The two flanking sequences of the host protein, called the N- and C-exteins, are subsequently ligated with a native p
요약	During this process, the intein breaks two peptide bonds and forms a third. Taking advantage of the intein's ability to catalyze these reactions, both within the natural host as well as in vitro for biotechnological applications, provides an att
요약	Our work focuses on two of the three inteins found in the human pathogen Mycobacterium tuberculosis (Mtu), RecA and SufB. The intein-interrupted proteins are important for the viability of Mtu. Preventing intein excision, and thus the formation
요약	Turning to methods of control for in vitro applications, we introduced a mutation in Mtu RecA that causes the intein to spontaneously form a thiazoline ring at the N-terminal splicing junction. While present, the thiazoline ring prevents any fur
요약	The final aspect of our work is based on the intriguing hypothesis that inteins are not simply parasitic elements, but offer a beneficial protein-level control of host protein function. We demonstrated that Mtu SufB activity is inhibited in vivo
요약	Overall, this work investigates strategies for controlling inteins in the realms of drug development, protein purification, and host regulation and stress response.
일반주제명	Chemical engineering. Biochemistry.
언어	영어
기본자료 저록	Dissertation Abstracts International79-12B(E). Dissertation Abstract International
대출바로가기	http://www.riss.kr/pdu/ddodLink.do?id=T14996731