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Homeostatic Responses of the Enteric Cholinergic System in Stress and Enteritis

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개인저자Pohl, Calvin Seneca.
단체저자명Michigan State University. Comparative Medicine and Integrative Biology - Doctor of Philosophy.
서명/저자사항Homeostatic Responses of the Enteric Cholinergic System in Stress and Enteritis.
발행사항[S.l.] : Michigan State University., 2018
발행사항Ann Arbor : ProQuest Dissertations & Theses, 2018
형태사항239 p.
소장본 주기School code: 0128.
ISBN9780355968804
일반주기 Source: Dissertation Abstracts International, Volume: 79-10(E), Section: B.
Adviser: Adam J. Moeser.
요약Stressful, traumatic events are a well-recognized trigger leading to acute and chronic gastrointestinal (GI) disease like Irritable Bowel Syndrome (IBS) or Inflammatory Bowel Disease (IBD). Two major types of stress which are pervasive within th
요약The enteric cholinergic nervous system is a major regulator of GI homeostasis with broad regulatory roles over epithelial barrier permeability, epithelial cell secretion, smooth muscle contraction and motility, and immune activation. Though a ro
요약The objective of this dissertation was to determine if the enteric cholinergic nervous system contributed to GI disease under different types of environmental challenges including early life adversity, chronic stress and pathogen challenge. To a
요약The results presented here demonstrate that different types of stressors differentially impact the enteric cholinergic system. Following early life adversity, we observed a persistent upregulation of the enteric cholinergic system, which predisp
일반주제명Physiology.
Immunology.
Neurosciences.
언어영어
기본자료 저록Dissertation Abstracts International79-10B(E).
Dissertation Abstract International
대출바로가기http://www.riss.kr/pdu/ddodLink.do?id=T14998481

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