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020 ▼a 9780355968804
035 ▼a (MiAaPQ)AAI10822515
035 ▼a (MiAaPQ)grad.msu:16107
040 ▼a MiAaPQ ▼c MiAaPQ ▼d 248032
0491 ▼f DP
0820 ▼a 612
1001 ▼a Pohl, Calvin Seneca.
24510 ▼a Homeostatic Responses of the Enteric Cholinergic System in Stress and Enteritis.
260 ▼a [S.l.] : ▼b Michigan State University., ▼c 2018
260 1 ▼a Ann Arbor : ▼b ProQuest Dissertations & Theses, ▼c 2018
300 ▼a 239 p.
500 ▼a Source: Dissertation Abstracts International, Volume: 79-10(E), Section: B.
500 ▼a Adviser: Adam J. Moeser.
5021 ▼a Thesis (Ph.D.)--Michigan State University, 2018.
520 ▼a Stressful, traumatic events are a well-recognized trigger leading to acute and chronic gastrointestinal (GI) disease like Irritable Bowel Syndrome (IBS) or Inflammatory Bowel Disease (IBD). Two major types of stress which are pervasive within th
520 ▼a The enteric cholinergic nervous system is a major regulator of GI homeostasis with broad regulatory roles over epithelial barrier permeability, epithelial cell secretion, smooth muscle contraction and motility, and immune activation. Though a ro
520 ▼a The objective of this dissertation was to determine if the enteric cholinergic nervous system contributed to GI disease under different types of environmental challenges including early life adversity, chronic stress and pathogen challenge. To a
520 ▼a The results presented here demonstrate that different types of stressors differentially impact the enteric cholinergic system. Following early life adversity, we observed a persistent upregulation of the enteric cholinergic system, which predisp
590 ▼a School code: 0128.
650 4 ▼a Physiology.
650 4 ▼a Immunology.
650 4 ▼a Neurosciences.
690 ▼a 0719
690 ▼a 0982
690 ▼a 0317
71020 ▼a Michigan State University. ▼b Comparative Medicine and Integrative Biology - Doctor of Philosophy.
7730 ▼t Dissertation Abstracts International ▼g 79-10B(E).
773 ▼t Dissertation Abstract International
790 ▼a 0128
791 ▼a Ph.D.
792 ▼a 2018
793 ▼a English
85640 ▼u http://www.riss.kr/pdu/ddodLink.do?id=T14998481 ▼n KERIS
980 ▼a 201812 ▼f 2019
990 ▼a 관리자 ▼b 관리자