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Vitamin D and Regulation of Pericyte Function

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개인저자Jamali, Nasim.
단체저자명The University of Wisconsin - Madison. Cellular anf Molecular Biology.
서명/저자사항Vitamin D and Regulation of Pericyte Function.
발행사항[S.l.] : The University of Wisconsin - Madison., 2017
발행사항Ann Arbor : ProQuest Dissertations & Theses, 2017
형태사항372 p.
소장본 주기School code: 0262.
ISBN9780438029828
일반주기 Source: Dissertation Abstracts International, Volume: 79-10(E), Section: B.
Adviser: Nader Sheibani.
요약Vitamin D deficiency has been linked to pathogenesis of many diseases including cardiovascular, cancer, and various eye diseases. In recent years, important roles for vitamin D in regulation of immune function, inflammation, angiogenesis, and ag
요약The majority of vitamin D action is mediated through vitamin D receptor (Vdr). However, the role Vdr expression plays in vascular development and inhibition of neovascularization by vitamin D remained unknown. In chapter two, I determined the im
요약Our previous studies indicated that calcitriol has no significant effect on retinal EC function in culture. However, calcitriol inhibited capillary morphogenesis of EC in Matrigel. As PC, play essential roles during angiogenesis, including vascu
요약To further investigate whether the observed effects of calcitriol on PC is organ specific, I also evaluated the response of lung PC to calcitriol. Similar to retinal PC, calcitriol reduced proliferation and migration of lung PC as well as increa
요약Taken together, these studies established an important role for vitamin D and its receptor in regulation of perivascular supporting cell function. I propose Vdr expression is important during maturation of developing vasculature by promoting the
일반주제명Cellular biology.
Molecular biology.
Biology.
언어영어
기본자료 저록Dissertation Abstracts International79-10B(E).
Dissertation Abstract International
대출바로가기http://www.riss.kr/pdu/ddodLink.do?id=T14996651

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