| LDR | | 02647nmm uu200469 4500 |
| 001 | | 000000334658 |
| 005 | | 20240805180743 |
| 008 | | 181129s2017 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438029828 |
| 035 | |
▼a (MiAaPQ)AAI10623199 |
| 035 | |
▼a (MiAaPQ)wisc:14808 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 082 | 0 |
▼a 574 |
| 100 | 1 |
▼a Jamali, Nasim. |
| 245 | 10 |
▼a Vitamin D and Regulation of Pericyte Function. |
| 260 | |
▼a [S.l.] :
▼b The University of Wisconsin - Madison.,
▼c 2017 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2017 |
| 300 | |
▼a 372 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-10(E), Section: B. |
| 500 | |
▼a Adviser: Nader Sheibani. |
| 502 | 1 |
▼a Thesis (Ph.D.)--The University of Wisconsin - Madison, 2017. |
| 520 | |
▼a Vitamin D deficiency has been linked to pathogenesis of many diseases including cardiovascular, cancer, and various eye diseases. In recent years, important roles for vitamin D in regulation of immune function, inflammation, angiogenesis, and ag |
| 520 | |
▼a The majority of vitamin D action is mediated through vitamin D receptor (Vdr). However, the role Vdr expression plays in vascular development and inhibition of neovascularization by vitamin D remained unknown. In chapter two, I determined the im |
| 520 | |
▼a Our previous studies indicated that calcitriol has no significant effect on retinal EC function in culture. However, calcitriol inhibited capillary morphogenesis of EC in Matrigel. As PC, play essential roles during angiogenesis, including vascu |
| 520 | |
▼a To further investigate whether the observed effects of calcitriol on PC is organ specific, I also evaluated the response of lung PC to calcitriol. Similar to retinal PC, calcitriol reduced proliferation and migration of lung PC as well as increa |
| 520 | |
▼a Taken together, these studies established an important role for vitamin D and its receptor in regulation of perivascular supporting cell function. I propose Vdr expression is important during maturation of developing vasculature by promoting the |
| 590 | |
▼a School code: 0262. |
| 650 | 4 |
▼a Cellular biology. |
| 650 | 4 |
▼a Molecular biology. |
| 650 | 4 |
▼a Biology. |
| 690 | |
▼a 0379 |
| 690 | |
▼a 0307 |
| 690 | |
▼a 0306 |
| 710 | 20 |
▼a The University of Wisconsin - Madison.
▼b Cellular anf Molecular Biology. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-10B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0262 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2017 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T14996651
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자 |