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Biochemical and Genetic Characterization of Factors that Influence Branchsite Selection during Pre-mRNA Splicing in Yeast
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| 자료유형 | E-Book |
|---|---|
| 개인저자 | Carrocci, Tucker Joe. |
| 단체저자명 | The University of Wisconsin - Madison. Biochemistry-ALS. |
| 서명/저자사항 | Biochemical and Genetic Characterization of Factors that Influence Branchsite Selection during Pre-mRNA Splicing in Yeast. |
| 발행사항 | [S.l.] : The University of Wisconsin - Madison., 2017 |
| 발행사항 | Ann Arbor : ProQuest Dissertations & Theses, 2017 |
| 형태사항 | 268 p. |
| 소장본 주기 | School code: 0262. |
| ISBN | 9780438024175 |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 79-10(E), Section: B.
Adviser: Aaron A. Hoskins. |
| 요약 | RNA splicing plays many critical roles in eukaryotic gene expression, yet even 40 years after its discovery, the mechanism by which the spliceosome recognizes and removes introns is still poorly understood. In my thesis, I describe methods to pr |
| 요약 | In my thesis, I discuss methods to label RNA fluorescently. I used MS2 fusion proteins tags to the label RNAs in living yeast using small molecule fluorophores. These tags allow for visualization of localized RNAs and demonstrate that organic fl |
| 요약 | In the second portion of my thesis, I discuss work on the role of splicing factors that contribute to branchsite choice. I explored the role of cancer causing mutations in a protein called SF3b1 using the yeast spliceosome. Mutations of SF3b1 re |
| 요약 | Finally, I used smFRET to observe dynamics in the splicing factor Prp5, which ensures proper branchsite usage by the spliceosome. I showed that Prp5 primarily adopts an open state in the absence of ATP and RNA but transitions to a closed state u |
| 일반주제명 | Biochemistry. |
| 언어 | 영어 |
| 기본자료 저록 | Dissertation Abstracts International79-10B(E). Dissertation Abstract International |
| 대출바로가기 | http://www.riss.kr/pdu/ddodLink.do?id=T14996579 |
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| No. | 등록번호 | 청구기호 | 소장처 | 도서상태 | 반납예정일 | 예약 | 서비스 | 매체정보 |
|---|---|---|---|---|---|---|---|---|
| 1 | WE00028913 | 574 | 가야대학교// | 대출가능 |
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