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Elucidating the Role of GODZ-Mediated Palmitoylation in Controlling GABAergic Inhibition
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| 자료유형 | E-Book |
|---|---|
| 개인저자 | Kilpatrick, Casey. |
| 단체저자명 | The Pennsylvania State University. Biochemistry, Microbiology and Molecular Biology. |
| 서명/저자사항 | Elucidating the Role of GODZ-Mediated Palmitoylation in Controlling GABAergic Inhibition. |
| 발행사항 | [S.l.] : The Pennsylvania State University., 2016 |
| 발행사항 | Ann Arbor : ProQuest Dissertations & Theses, 2016 |
| 형태사항 | 145 p. |
| 소장본 주기 | School code: 0176. |
| ISBN | 9780438135185 |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B.
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| 요약 | Palmitoylation involves the addition of a 16-carbon fatty acid chain to cysteine residues, which increases the hydrophobicity of the target protein. This modification functionally influences membrane targeting, protein conformational state, comp |
| 요약 | GABAARs are heteropentameric chloride channels responsible for mediating phasic inhibitory neurotransmission in the brain. The gamma2 subunit of GABAARs is critically important for trafficking of these receptors to the synapse and for normal GAB |
| 요약 | The main objective of this dissertation was to further elucidate the mechanism by which GODZ-mediated palmitoylation controls GABAergic inhibition in vivo, by utilizing GODZ KO mice. I screened for candidate novel substrates of GODZ using a com |
| 요약 | The next objective was to assess the precise localization of GODZ in the Golgi apparatus using cis- and trans-Golgi markers in HEK 293T cells to gain further insights into the subcellular role of GODZ-mediated palmitoylation. GODZ was more stron |
| 요약 | Finally, synaptic deficits seen in GODZ KO neurons could also be explained by the loss of NL2 palmitoylation. NL2 is localized preferentially to inhibitory synapses where it is important for synapse maturation. Moreover, knockdown of NL2 leads t |
| 일반주제명 | Biochemistry. Neurosciences. |
| 언어 | 영어 |
| 기본자료 저록 | Dissertation Abstracts International79-12B(E). Dissertation Abstract International |
| 대출바로가기 | http://www.riss.kr/pdu/ddodLink.do?id=T15000679 |
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| No. | 등록번호 | 청구기호 | 소장처 | 도서상태 | 반납예정일 | 예약 | 서비스 | 매체정보 |
|---|---|---|---|---|---|---|---|---|
| 1 | WE00028610 | 574 | 가야대학교// | 대출가능 |
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