| LDR | | 02570nmm uu200421 4500 |
| 001 | | 000000334283 |
| 005 | | 20240805180009 |
| 008 | | 181129s2016 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438135185 |
| 035 | |
▼a (MiAaPQ)AAI10903693 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 082 | 0 |
▼a 574 |
| 100 | 1 |
▼a Kilpatrick, Casey. |
| 245 | 10 |
▼a Elucidating the Role of GODZ-Mediated Palmitoylation in Controlling GABAergic Inhibition. |
| 260 | |
▼a [S.l.] :
▼b The Pennsylvania State University.,
▼c 2016 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2016 |
| 300 | |
▼a 145 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B. |
| 502 | 1 |
▼a Thesis (Ph.D.)--The Pennsylvania State University, 2016. |
| 520 | |
▼a Palmitoylation involves the addition of a 16-carbon fatty acid chain to cysteine residues, which increases the hydrophobicity of the target protein. This modification functionally influences membrane targeting, protein conformational state, comp |
| 520 | |
▼a GABAARs are heteropentameric chloride channels responsible for mediating phasic inhibitory neurotransmission in the brain. The gamma2 subunit of GABAARs is critically important for trafficking of these receptors to the synapse and for normal GAB |
| 520 | |
▼a The main objective of this dissertation was to further elucidate the mechanism by which GODZ-mediated palmitoylation controls GABAergic inhibition in vivo, by utilizing GODZ KO mice. I screened for candidate novel substrates of GODZ using a com |
| 520 | |
▼a The next objective was to assess the precise localization of GODZ in the Golgi apparatus using cis- and trans-Golgi markers in HEK 293T cells to gain further insights into the subcellular role of GODZ-mediated palmitoylation. GODZ was more stron |
| 520 | |
▼a Finally, synaptic deficits seen in GODZ KO neurons could also be explained by the loss of NL2 palmitoylation. NL2 is localized preferentially to inhibitory synapses where it is important for synapse maturation. Moreover, knockdown of NL2 leads t |
| 590 | |
▼a School code: 0176. |
| 650 | 4 |
▼a Biochemistry. |
| 650 | 4 |
▼a Neurosciences. |
| 690 | |
▼a 0487 |
| 690 | |
▼a 0317 |
| 710 | 20 |
▼a The Pennsylvania State University.
▼b Biochemistry, Microbiology and Molecular Biology. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-12B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0176 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2016 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T15000679
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자 |