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Investigating Non-canonical Mechanisms of Receptor Tyrosine Kinase Signaling
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| 자료유형 | E-Book |
|---|---|
| 개인저자 | Frazier, Nicole Amber Michael. |
| 단체저자명 | University of California, San Francisco. Biochemistry and Molecular Biology. |
| 서명/저자사항 | Investigating Non-canonical Mechanisms of Receptor Tyrosine Kinase Signaling. |
| 발행사항 | [S.l.] : University of California, San Francisco., 2018 |
| 발행사항 | Ann Arbor : ProQuest Dissertations & Theses, 2018 |
| 형태사항 | 97 p. |
| 소장본 주기 | School code: 0034. |
| ISBN | 9780438250444 |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B.
Adviser: Natalia Jura. |
| 요약 | This thesis examines multiple facets of the human epidermal growth factor receptor-3 (HER3) signaling. Receptor tyrosine kinases are typically activated through ligand-dependent homodimerization resulting in trans-autophosphorylation and subsequ |
| 요약 | The MET receptor, along with the Ron receptor, make up the MET receptor family. Like the HER family, the MET receptor also plays a role in cancer progression particularly in driving invasiveness and metastasis. The most common mechanism of activ |
| 요약 | The first chapter of this thesis elucidates how overexpression of MET in cancer mediates phosphorylation of HER3 in the Golgi apparatus. The second chapter investigates the contributions of individual PI3K binding sites, and describes a new role |
| 일반주제명 | Molecular biology. Cellular biology. Biochemistry. |
| 언어 | 영어 |
| 기본자료 저록 | Dissertation Abstracts International79-12B(E). Dissertation Abstract International |
| 대출바로가기 | http://www.riss.kr/pdu/ddodLink.do?id=T14999216 |
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| No. | 등록번호 | 청구기호 | 소장처 | 도서상태 | 반납예정일 | 예약 | 서비스 | 매체정보 |
|---|---|---|---|---|---|---|---|---|
| 1 | WE00028525 | 574 | 가야대학교// | 대출가능 |
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