| LDR | | 02182nmm uu200445 4500 |
| 001 | | 000000334198 |
| 005 | | 20240805175326 |
| 008 | | 181129s2018 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438250444 |
| 035 | |
▼a (MiAaPQ)AAI10828783 |
| 035 | |
▼a (MiAaPQ)ucsf:11647 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 082 | 0 |
▼a 574 |
| 100 | 1 |
▼a Frazier, Nicole Amber Michael. |
| 245 | 10 |
▼a Investigating Non-canonical Mechanisms of Receptor Tyrosine Kinase Signaling. |
| 260 | |
▼a [S.l.] :
▼b University of California, San Francisco.,
▼c 2018 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2018 |
| 300 | |
▼a 97 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B. |
| 500 | |
▼a Adviser: Natalia Jura. |
| 502 | 1 |
▼a Thesis (Ph.D.)--University of California, San Francisco, 2018. |
| 520 | |
▼a This thesis examines multiple facets of the human epidermal growth factor receptor-3 (HER3) signaling. Receptor tyrosine kinases are typically activated through ligand-dependent homodimerization resulting in trans-autophosphorylation and subsequ |
| 520 | |
▼a The MET receptor, along with the Ron receptor, make up the MET receptor family. Like the HER family, the MET receptor also plays a role in cancer progression particularly in driving invasiveness and metastasis. The most common mechanism of activ |
| 520 | |
▼a The first chapter of this thesis elucidates how overexpression of MET in cancer mediates phosphorylation of HER3 in the Golgi apparatus. The second chapter investigates the contributions of individual PI3K binding sites, and describes a new role |
| 590 | |
▼a School code: 0034. |
| 650 | 4 |
▼a Molecular biology. |
| 650 | 4 |
▼a Cellular biology. |
| 650 | 4 |
▼a Biochemistry. |
| 690 | |
▼a 0307 |
| 690 | |
▼a 0379 |
| 690 | |
▼a 0487 |
| 710 | 20 |
▼a University of California, San Francisco.
▼b Biochemistry and Molecular Biology. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-12B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0034 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T14999216
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자 |