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Multivariate Analysis to Identify Potential Biomarkers for Prognosis and Treatment Resistance in Head and Neck Cancer Patients
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| 자료유형 | E-Book |
|---|---|
| 개인저자 | Wicker, Christina Ann. |
| 단체저자명 | University of Kentucky. Toxicology and Cancer Biology. |
| 서명/저자사항 | Multivariate Analysis to Identify Potential Biomarkers for Prognosis and Treatment Resistance in Head and Neck Cancer Patients. |
| 발행사항 | [S.l.] : University of Kentucky., 2017 |
| 발행사항 | Ann Arbor : ProQuest Dissertations & Theses, 2017 |
| 형태사항 | 229 p. |
| 소장본 주기 | School code: 0102. |
| ISBN | 9780438239401 |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B.
Adviser: Tadahide Izumi. |
| 요약 | It is estimated that nearly 50,000 individuals in the United States will be diagnosed with head and neck cancer in 2017 (American Cancer Society www.cancer.org). Ninety percent of oral cancers are head and neck squamous cell carcinoma (HNSCC). M |
| 요약 | Abnormal localization and overexpression of base excision repair protein and transcriptional regulator Apurinic/Apyrimidic endonuclease (APE1) has been associated with treatment resistance and poor prognosis. Therefore, we explored mechanisms fo |
| 요약 | Because oxidative stress heavily influences APE1's expression and transcriptional regulatory activities, we examined genes involved in oxidative stress management, including SOD3 and NRF2. PPARGC1A, a NRF2 transcriptional co-activator, was also |
| 요약 | To examine possible mechanisms for how APE1 regulates expression of tumor suppressors and antioxidants, digital image analysis of immunohistochemistry staining was used to identify alterations in protein expression. Nuclear and total cellular pr |
| 요약 | Most importantly, potential prognostic biomarkers for use in early cancer development were identified. Identifying poor prognosis in early cancer development allows the possibility of improved treatment strategies, which could prevent invasive c |
| 일반주제명 | Oncology. Molecular biology. Bioinformatics. |
| 언어 | 영어 |
| 기본자료 저록 | Dissertation Abstracts International79-12B(E). Dissertation Abstract International |
| 대출바로가기 | http://www.riss.kr/pdu/ddodLink.do?id=T15001225 |
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| No. | 등록번호 | 청구기호 | 소장처 | 도서상태 | 반납예정일 | 예약 | 서비스 | 매체정보 |
|---|---|---|---|---|---|---|---|---|
| 1 | WE00026487 | 616.99 | 가야대학교// | 대출가능 |
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