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Development, Validation, and Translation of a Respiratory Motion Model-Based 4DCT Technique for Use as a Clinical Protocol for Radiation Therapy Treatment Planning

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개인저자O'Connell, Dylan Patrick.
단체저자명University of California, Los Angeles. Biomedical Physics.
서명/저자사항Development, Validation, and Translation of a Respiratory Motion Model-Based 4DCT Technique for Use as a Clinical Protocol for Radiation Therapy Treatment Planning.
발행사항[S.l.] : University of California, Los Angeles., 2018
발행사항Ann Arbor : ProQuest Dissertations & Theses, 2018
형태사항143 p.
소장본 주기School code: 0031.
ISBN9780438002296
일반주기 Source: Dissertation Abstracts International, Volume: 79-10(E), Section: B.
Adviser: Daniel A. Low.
요약Breathing motion in radiotherapy is commonly managed with four-dimensional computed tomography (4DCT). 4DCT datasets consist of multiple breathing-gated images that display motion of the subject's anatomy over a breathing period. Commercial 4DCT
요약A validation study was conducted involving comparing 5DCT images to commercial 4DCT using an animal model. Reproducible and periodic breathing patterns were achieved through mechanical ventilation and image similarity was quantified using landma
요약Differences in measured tumor motion between 5DCT and commercial 4DCT were examined in a cohort of 20 lung cancer patients. Solutions for the unique challenges of using model model-based techniques clinically, such as appropriate amplitude inter
요약A quality management program was developed to ensure the safety of the protocol using risk analysis methods such as process mapping and failure modes and effects analysis. In addition, safety of the in-house software required to implement the te
요약The physiological significance of the 5D model parameters was investigated, particularly their dependence on breathing rate during acquisition. It was shown that the model parameter relating tissue motion to breathing amplitude was largely invar
요약A prospective scanning method was developed to reduce the number of fast helical scans, and associated imaging dose, necessary to perform 5DCT while maintaining motion modeling accuracy. A simulation study was conducted using patient breathing t
일반주제명Medical imaging.
언어영어
기본자료 저록Dissertation Abstracts International79-10B(E).
Dissertation Abstract International
대출바로가기http://www.riss.kr/pdu/ddodLink.do?id=T14998761

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