| LDR | | 02361nmm uu200433 4500 |
| 001 | | 000000334697 |
| 005 | | 20240805180831 |
| 008 | | 181129s2018 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438033498 |
| 035 | |
▼a (MiAaPQ)AAI10746390 |
| 035 | |
▼a (MiAaPQ)unc:17515 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 082 | 0 |
▼a 575 |
| 100 | 1 |
▼a Coffey, Alisha Renee. |
| 245 | 10 |
▼a Systems Genetics Approach to Defining Genetic and MicroRNA Association with Diet-Associated Atherosclerosis. |
| 260 | |
▼a [S.l.] :
▼b The University of North Carolina at Chapel Hill.,
▼c 2018 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2018 |
| 300 | |
▼a 150 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-10(E), Section: B. |
| 500 | |
▼a Advisers: Brian J. Bennett |
| 502 | 1 |
▼a Thesis (Ph.D.)--The University of North Carolina at Chapel Hill, 2018. |
| 520 | |
▼a Atherosclerosis is a progressive condition that can develop over the course of decades, and eventually lead to cardiovascular disease, which is the leading cause of death in the world. Metabolic imbalance in the liver can cause dyslipidemia (abn |
| 520 | |
▼a MicroRNAs (miRNAs) have emerged as important post-transcriptional regulators of gene expression in various biological and pathological processes, and have been shown to be dysregulated in atherosclerosis. Most previous mouse studies of miRNAs in |
| 520 | |
▼a The majority of previous studies on the cardiovascular disease risk factor and liver metabolite TMAO focus on its regulation by the gut microbiota as well as some host liver enzymes. However, there have been very few studies to investigate the e |
| 520 | |
▼a The findings from this body of work contribute to the field by addressing two major knowledge gaps, and warrant further study and validation in the context of atherosclerosis. |
| 590 | |
▼a School code: 0153. |
| 650 | 4 |
▼a Genetics. |
| 650 | 4 |
▼a Molecular biology. |
| 690 | |
▼a 0369 |
| 690 | |
▼a 0307 |
| 710 | 20 |
▼a The University of North Carolina at Chapel Hill.
▼b Genetics and Molecular Biology. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-10B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0153 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T14996889
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자 |