| LDR | | 02079nmm uu200421 4500 |
| 001 | | 000000334588 |
| 005 | | 20240805180617 |
| 008 | | 181129s2017 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438373877 |
| 035 | |
▼a (MiAaPQ)AAI10281439 |
| 035 | |
▼a (MiAaPQ)wisc:14401 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 082 | 0 |
▼a 574.191 |
| 100 | 1 |
▼a Larson, Joshua Donald. |
| 245 | 14 |
▼a The Spliceosome E Complex Fine-Tunes 5' Splice Site Interactions. |
| 260 | |
▼a [S.l.] :
▼b The University of Wisconsin - Madison.,
▼c 2017 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2017 |
| 300 | |
▼a 228 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 80-01(E), Section: B. |
| 500 | |
▼a Adviser: Aaron A. Hoskins. |
| 502 | 1 |
▼a Thesis (Ph.D.)--The University of Wisconsin - Madison, 2017. |
| 520 | |
▼a Removal of introns from pre-mRNAs by the spliceosome is an essential cellular process in eukaryotes. The spliceosome is a macromolecular machine composed of five small nuclear ribonuclearprotein particles (snRNPs). These snRNPs assemble on intr |
| 520 | |
▼a To study the dynamics of E complex formation, I designed a novel microscope platform and constructed a multi-wavelength micromirror total internal reflectance microscope capable of monitoring the composition and dynamics of complex macromolecula |
| 520 | |
▼a The results presented in this thesis reveal that the majority of E complex forms transiently via a branched pathway with little commitment of a particular pre-mRNA or 5' SS/BS pair to subsequent splicing. Despite transient E complex formation, U |
| 590 | |
▼a School code: 0262. |
| 650 | 4 |
▼a Biophysics. |
| 650 | 4 |
▼a Biochemistry. |
| 690 | |
▼a 0786 |
| 690 | |
▼a 0487 |
| 710 | 20 |
▼a The University of Wisconsin - Madison.
▼b Biophysics. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 80-01B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0262 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2017 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T14996581
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자 |