| LDR | | 02499nmm uu200421 4500 |
| 001 | | 000000334548 |
| 005 | | 20240805180527 |
| 008 | | 181129s2018 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438151161 |
| 035 | |
▼a (MiAaPQ)AAI10243619 |
| 035 | |
▼a (MiAaPQ)uiowa:14847 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 082 | 0 |
▼a 616.079 |
| 100 | 1 |
▼a Mambetsariev, Nurbek. |
| 245 | 10 |
▼a Mechanisms of TRAF3 Mediated Regulation of B Cell Survival. |
| 260 | |
▼a [S.l.] :
▼b The University of Iowa.,
▼c 2018 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2018 |
| 300 | |
▼a 145 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B. |
| 500 | |
▼a Adviser: Gail A. Bishop. |
| 502 | 1 |
▼a Thesis (Ph.D.)--The University of Iowa, 2018. |
| 520 | |
▼a The adaptor protein TNF receptor-associated factor 3 (TRAF3) regulates signaling through B lymphocyte receptors, including CD40, BAFF receptor and Toll-like receptors, and also plays a critical role inhibiting B cell homoeostatic survival. Consi |
| 520 | |
▼a We show here that TRAF3 is a resident nuclear protein that associated with the transcriptional regulator cyclic AMP response element binding protein (CREB) in both mouse and human B cells. The TRAF-C domain of TRAF3 was necessary and sufficient |
| 520 | |
▼a We also show that TRAF3 deficiency led to induction of two proteins important for glucose metabolism, Glut1 and Hexokinase 2 (HXK2). This was associated with increased glucose uptake. In the absence of TRAF3, anaerobic glycolysis and oxidative p |
| 520 | |
▼a Finally, loss of TRAF3 resulted in the induction of the pro-survival kinase proviral insertion in murine lymphoma 2 (Pim2) in B cells independently of non --canonical NF-kappaB activation. TRAF3-deficient B cells and multiple myeloma cells displ |
| 520 | |
▼a Collectively, these findings provide insight into how TRAF3 regulates B cell survival. Our improved understanding of how loss of TRAF3 promotes development of B cell malignancies allows for the development of novel therapeutic strategies that ta |
| 590 | |
▼a School code: 0096. |
| 650 | 4 |
▼a Immunology. |
| 690 | |
▼a 0982 |
| 710 | 20 |
▼a The University of Iowa.
▼b Immunology. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-12B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0096 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T14996542
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자 |