| LDR | | 03041nmm uu200469 4500 |
| 001 | | 000000334503 |
| 005 | | 20240805180432 |
| 008 | | 181129s2016 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438170162 |
| 035 | |
▼a (MiAaPQ)AAI10189735 |
| 035 | |
▼a (MiAaPQ)umn:17065 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 082 | 0 |
▼a 540 |
| 100 | 1 |
▼a Gruba, Sarah Melissa. |
| 245 | 10 |
▼a Exploration of Platelet and Mast Cell Communication: A Study of Membrane Lipids, Asthma, and Inflammation. |
| 260 | |
▼a [S.l.] :
▼b University of Minnesota.,
▼c 2016 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2016 |
| 300 | |
▼a 170 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B. |
| 500 | |
▼a Adviser: Christy L. Haynes. |
| 502 | 1 |
▼a Thesis (Ph.D.)--University of Minnesota, 2016. |
| 520 | |
▼a This work examines how environmental factors such as lipid membrane concentration, opioid agonist exposure, and inflammatory diseases impact cell communication. It explores the use of different cell models, specifically platelets and mast cells, |
| 520 | |
▼a Platelets are cell-like bodies that travel through the bloodstream and are known for their role in hemostasis and diseases like stroke and myocardial infarction. They have also been implicated in inflammatory diseases such as asthma. In addition |
| 520 | |
▼a In contrast, mast cells are found throughout the body in connective tissue and are one of the immune system's first lines of defense. They are primarily known for their role in allergies and asthma. Upon detection of antigens that they are sensi |
| 520 | |
▼a Chapter One reviews single cell analysis techniques with a particular emphasis on the techniques used in this thesis, including electrochemistry and mass spectrometry. |
| 520 | |
▼a Chapter Two through four are focused on understanding how variations in membrane lipids and structure affect platelet function and exocytosis in general. Chapter Two focuses on understanding the variations that the fusion pore undergoes when gra |
| 520 | |
▼a Chapter Five and Six progresses from lipid function into developing a better understanding of how platelets respond to their environment, particularly in the context of inflammatory diseases. Chapter Five's focus is on platelet response to opioi |
| 520 | |
▼a Chapter Seven and Eight focus on mouse peritoneal mast cell (MPMC) function in the context of inflammatory diseases including allergic asthma and neurogenic inflammation, respectively. Chapter Seven aims to state the importance of understanding |
| 590 | |
▼a School code: 0130. |
| 650 | 4 |
▼a Chemistry. |
| 650 | 4 |
▼a Biochemistry. |
| 690 | |
▼a 0485 |
| 690 | |
▼a 0487 |
| 710 | 20 |
▼a University of Minnesota.
▼b Chemistry. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-12B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0130 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2016 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T14996497
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자 |