| LDR | | 02546nmm uu200421 4500 |
| 001 | | 000000334494 |
| 005 | | 20240805180421 |
| 008 | | 181129s2016 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438001114 |
| 035 | |
▼a (MiAaPQ)AAI10189602 |
| 035 | |
▼a (MiAaPQ)wisc:13539 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 082 | 0 |
▼a 574 |
| 100 | 1 |
▼a Hoang, Trish T. |
| 245 | 10 |
▼a Molecular Basis of Angiogenesis and Neuroprotection by Angiogenin. |
| 260 | |
▼a [S.l.] :
▼b The University of Wisconsin - Madison.,
▼c 2016 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2016 |
| 300 | |
▼a 294 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-10(E), Section: B. |
| 500 | |
▼a Adviser: Ronald T. Raines. |
| 502 | 1 |
▼a Thesis (Ph.D.)--The University of Wisconsin - Madison, 2016. |
| 520 | |
▼a As two of the leading causes of death, cancer and neurodegenerative diseases (NDs) are certainly topics of interest for researchers worldwide. Proteins that are implicated in both diseases are particularly interesting. These molecules often serv |
| 520 | |
▼a Angiogenin (ANG) is one of the few proteins that serve specific functions in both diseases. An excess of ANG is associated with cancer, while a lack of ANG contributes to NDs. As diseases result from imbalanced ANG function, studying ANG is not |
| 520 | |
▼a Although the molecular roles of ANG are not understood completely in either diseases, a central theme emerging from ANG actions is its re-programming of protein synthesis. The purposes of this thesis are to explore the effect of ANG on protein s |
| 520 | |
▼a In CHAPTER 1, I summarize the large body of evidence indicating the important role of ANG in cancer and NDs. To support cancer development, ANG induces angiogenesis. In CHAPTER 2, I report on the unprecedented mechanism of signal transduction by |
| 520 | |
▼a By elucidating the elegant network of ANG actions, features of ANG required for a particular pathway might be used to design ANG-based therapeutics. CHAPTER 4 outlines several future directions for developing ANG therapeutics that can selectivel |
| 590 | |
▼a School code: 0262. |
| 650 | 4 |
▼a Biochemistry. |
| 690 | |
▼a 0487 |
| 710 | 20 |
▼a The University of Wisconsin - Madison.
▼b Biochemistry. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-10B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0262 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2016 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T14996490
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자 |