| LDR | | 02536nmm uu200421 4500 |
| 001 | | 000000334485 |
| 005 | | 20240805180410 |
| 008 | | 181129s2016 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438170117 |
| 035 | |
▼a (MiAaPQ)AAI10189319 |
| 035 | |
▼a (MiAaPQ)umn:16990 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 082 | 0 |
▼a 612 |
| 100 | 1 |
▼a Houang, Evelyne Morgane. |
| 245 | 10 |
▼a Copolymer-based Membrane Stabilizers for Duchenne Muscular Dystrophy. |
| 260 | |
▼a [S.l.] :
▼b University of Minnesota.,
▼c 2016 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2016 |
| 300 | |
▼a 172 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B. |
| 500 | |
▼a Adviser: Joseph M. Metzger. |
| 502 | 1 |
▼a Thesis (Ph.D.)--University of Minnesota, 2016. |
| 520 | |
▼a The overarching objective of this work centers on a structure-function approach to investigate the mechanism of action of synthetic copolymer-based membrane stabilization in the context of Duchenne Muscular Dystrophy (DMD). The guiding theme is |
| 520 | |
▼a DMD is an X-linked recessive disease of marked striated muscle deterioration affecting 1 in 3500-5000 boys. DMD results from the lack of the cytoskeletal protein dystrophin, which is essential for maintaining the structural integrity of the musc |
| 520 | |
▼a The efficacy of P188 in protecting the dystrophic myocardium has been well established, but its effect on the dystrophic skeletal muscle has remained unclear. This work for the first time demonstrates that P188 stabilizes the dystrophic skeletal |
| 520 | |
▼a Very little is known on how P188 interacts with and stabilizes biological membranes. To fundamentally probe the mechanism of action of synthetic copolymers as membrane stabilizers, a structure-function approach was undertaken. The aim was to gai |
| 520 | |
▼a Finally, leveraging the power of supercomputational approaches, Molecular Dynamics simulations were developed to further evaluate and understand copolymer-membrane interactions at atom level resolution. Using increases in surface tension applied |
| 590 | |
▼a School code: 0130. |
| 650 | 4 |
▼a Physiology. |
| 690 | |
▼a 0719 |
| 710 | 20 |
▼a University of Minnesota.
▼b Integrative Biology and Physiology. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-12B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0130 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2016 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T14996482
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자 |