| LDR | | 01944nmm uu200385 4500 |
| 001 | | 000000334442 |
| 005 | | 20240805180318 |
| 008 | | 181129s2018 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438364912 |
| 035 | |
▼a (MiAaPQ)AAI10984432 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 082 | 0 |
▼a 617.6 |
| 100 | 1 |
▼a Yang, Xu. |
| 245 | 10 |
▼a Unconventional Protein Secretion of Keratin 75 by Ameloblasts In Vivo. |
| 260 | |
▼a [S.l.] :
▼b University of Pittsburgh.,
▼c 2018 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2018 |
| 300 | |
▼a 86 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 80-01(E), Section: B. |
| 500 | |
▼a Adviser: Elia Beniash. |
| 502 | 1 |
▼a Thesis (Ph.D.)--University of Pittsburgh, 2018. |
| 520 | |
▼a Keratin-75, originally identified as a hair follicle specific keratin, was recently discovered in enamel tissue. Individuals carrying a K75 A161T mutation presented with altered enamel structure and increased susceptibility to dental caries. The |
| 520 | |
▼a IF and IG-TEM data strongly indicate that K75, traditionally regarded as a component of cytoskeleton, is secreted by ameloblasts together with other EMPs. Since K75 does not have a signal peptide, how K75 is transported out of the cell is intrig |
| 520 | |
▼a In summary, we demonstrate that localization of K75 in ameloblasts is different from typical cytokeratins. It is secreted extracellularly with EMPs by secretory stage ameloblasts. Moreover, our results suggest that K75 utilizes a novel unconvent |
| 590 | |
▼a School code: 0178. |
| 650 | 4 |
▼a Dentistry. |
| 690 | |
▼a 0567 |
| 710 | 20 |
▼a University of Pittsburgh.
▼b Dental Medicine. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 80-01B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0178 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T15001401
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자 |