| LDR | | 02527nmm uu200421 4500 |
| 001 | | 000000334401 |
| 005 | | 20240805180229 |
| 008 | | 181129s2015 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438310131 |
| 035 | |
▼a (MiAaPQ)AAI10970774 |
| 035 | |
▼a (MiAaPQ)OhioLINK:osu1438185414 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 082 | 0 |
▼a 610 |
| 100 | 1 |
▼a Waters, Catherine Elizabeth. |
| 245 | 10 |
▼a Insights Into FHIT Loss-Induced Tumorigenesis. |
| 260 | |
▼a [S.l.] :
▼b The Ohio State University.,
▼c 2015 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2015 |
| 300 | |
▼a 128 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 80-01(E), Section: B. |
| 500 | |
▼a Adviser: Kay Huebner. |
| 502 | 1 |
▼a Thesis (Ph.D.)--The Ohio State University, 2015. |
| 520 | |
▼a Cancer cells display an elevated rate of genetic mutation at the single nucleotide and chromosome levels, termed genome instability. Genome instability is a facilitating hallmark of cancer in that it raises the probability of generating cancer-p |
| 520 | |
▼a Deletion within fragile site FRA3B, which overlaps exons of the FHIT gene, is a frequent and early genetic alteration in precancerous cells, resulting in reduced or lost Fhit protein expression. Loss of Fhit expression occurs in >50% of human c |
| 520 | |
▼a The cellular processes that can exploit Fhit loss-induced DNA damage and allow increased accumulation of genome alterations and point mutations in Fhit deficient cells and tissues have only recently been examined. APOBEC3B cytidine deaminase act |
| 520 | |
▼a Using data from The Cancer Genome Atlas, we show that FHIT-low/ APOBEC3B-high expressing lung adenocarcinomas display significantly increased numbers of APOBEC signature mutations. Tumor samples in this cohort with normal FHIT expression do not |
| 520 | |
▼a Collectively, these findings support a model where deregulation of the Fhit-TK1 pathway initiates genomic instability in early lesions, providing increased availability of unstable ssDNA regions that can be mutated by enzymes, such as APOBEC3B, |
| 590 | |
▼a School code: 0168. |
| 650 | 4 |
▼a Biomedical engineering. |
| 690 | |
▼a 0541 |
| 710 | 20 |
▼a The Ohio State University.
▼b Biomedical Sciences. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 80-01B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0168 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2015 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T15001360
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자 |