| LDR | | 01997nmm uu200397 4500 |
| 001 | | 000000334181 |
| 005 | | 20240805175306 |
| 008 | | 181129s2018 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438177734 |
| 035 | |
▼a (MiAaPQ)AAI10828658 |
| 035 | |
▼a (MiAaPQ)washington:18902 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 082 | 0 |
▼a 615 |
| 100 | 1 |
▼a Chapron, Alenka. |
| 245 | 10 |
▼a Renal Tubular Transport of Drugs in Healthy and Diseased Kidney. |
| 260 | |
▼a [S.l.] :
▼b University of Washington.,
▼c 2018 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2018 |
| 300 | |
▼a 176 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B. |
| 500 | |
▼a Adviser: Danny D. Shen. |
| 502 | 1 |
▼a Thesis (Ph.D.)--University of Washington, 2018. |
| 520 | |
▼a In this thesis work, I applied traditional and innovative bioengineering approaches to develop an in vitro model of renal proximal tubule with human proximal tubule epithelial cells (PTECs) that is particularly suited for drug transport studies. |
| 520 | |
▼a At the initial stage of our development, freshly isolated human PTECs were successfully expanded through conventional culturing, which afforded an adequate cell source. When passaged PTECs were grown on permeable supports, they maintained their |
| 520 | |
▼a The last part of my thesis work focused on alterations in renal secretory clearance of drugs in renal impairment. Dosing adjustments in chronic kidney diseases (CKD) have traditionally relied on serum creatinine as a biomarker of glomerular filt |
| 590 | |
▼a School code: 0250. |
| 650 | 4 |
▼a Pharmaceutical sciences. |
| 690 | |
▼a 0572 |
| 710 | 20 |
▼a University of Washington.
▼b Pharmaceutics. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-12B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0250 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T14999199
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자 |