| LDR | | 02103nmm uu200445 4500 |
| 001 | | 000000334165 |
| 005 | | 20240805175247 |
| 008 | | 181129s2018 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438177345 |
| 035 | |
▼a (MiAaPQ)AAI10828533 |
| 035 | |
▼a (MiAaPQ)washington:18860 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 082 | 0 |
▼a 576.6 |
| 100 | 1 |
▼a Plotnik, David Alan. |
| 245 | 14 |
▼a The Role of CS1 Fibronectin in HIV-1 Infection of alpha 4beta7+ T Lymphocytes. |
| 260 | |
▼a [S.l.] :
▼b University of Washington.,
▼c 2018 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2018 |
| 300 | |
▼a 198 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B. |
| 500 | |
▼a Adviser: Shiu-Lok Hu. |
| 502 | 1 |
▼a Thesis (Ph.D.)--University of Washington, 2018. |
| 520 | |
▼a A hallmark of Human Immunodeficiency Virus type 1 (HIV-1) pathogenesis is the profound depletion of CD4+ T lymphocytes within gut-associated lymphoid tissues (GALT), and persistent immune dysfunction at mucosal sites. It has been demonstrated th |
| 520 | |
▼a In this dissertation, I investigated the basis for HIV-alpha4 beta7 interaction in detail. I discovered that gp120 does not bind to alpha4beta7 as previously reported. Instead, I discovered that mammalian cell lines used to express recombinant g |
| 520 | |
▼a Collectively, these studies clarified the nature of HIV interactions with alpha4beta7, identified a novel role for fibronectins in HIV pathogenesis, and provided insight into how these interactions may be targeted therapeutically. |
| 590 | |
▼a School code: 0250. |
| 650 | 4 |
▼a Virology. |
| 650 | 4 |
▼a Pharmaceutical sciences. |
| 650 | 4 |
▼a Molecular biology. |
| 690 | |
▼a 0720 |
| 690 | |
▼a 0572 |
| 690 | |
▼a 0307 |
| 710 | 20 |
▼a University of Washington.
▼b Pharmaceutics. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-12B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0250 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T14999178
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자 |