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LDR02103nmm uu200445 4500
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008181129s2018 |||||||||||||||||c||eng d
020 ▼a 9780438177345
035 ▼a (MiAaPQ)AAI10828533
035 ▼a (MiAaPQ)washington:18860
040 ▼a MiAaPQ ▼c MiAaPQ ▼d 248032
0820 ▼a 576.6
1001 ▼a Plotnik, David Alan.
24514 ▼a The Role of CS1 Fibronectin in HIV-1 Infection of alpha 4beta7+ T Lymphocytes.
260 ▼a [S.l.] : ▼b University of Washington., ▼c 2018
260 1 ▼a Ann Arbor : ▼b ProQuest Dissertations & Theses, ▼c 2018
300 ▼a 198 p.
500 ▼a Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B.
500 ▼a Adviser: Shiu-Lok Hu.
5021 ▼a Thesis (Ph.D.)--University of Washington, 2018.
520 ▼a A hallmark of Human Immunodeficiency Virus type 1 (HIV-1) pathogenesis is the profound depletion of CD4+ T lymphocytes within gut-associated lymphoid tissues (GALT), and persistent immune dysfunction at mucosal sites. It has been demonstrated th
520 ▼a In this dissertation, I investigated the basis for HIV-alpha4 beta7 interaction in detail. I discovered that gp120 does not bind to alpha4beta7 as previously reported. Instead, I discovered that mammalian cell lines used to express recombinant g
520 ▼a Collectively, these studies clarified the nature of HIV interactions with alpha4beta7, identified a novel role for fibronectins in HIV pathogenesis, and provided insight into how these interactions may be targeted therapeutically.
590 ▼a School code: 0250.
650 4 ▼a Virology.
650 4 ▼a Pharmaceutical sciences.
650 4 ▼a Molecular biology.
690 ▼a 0720
690 ▼a 0572
690 ▼a 0307
71020 ▼a University of Washington. ▼b Pharmaceutics.
7730 ▼t Dissertation Abstracts International ▼g 79-12B(E).
773 ▼t Dissertation Abstract International
790 ▼a 0250
791 ▼a Ph.D.
792 ▼a 2018
793 ▼a English
85640 ▼u http://www.riss.kr/pdu/ddodLink.do?id=T14999178 ▼n KERIS
980 ▼a 201812 ▼f 2019
990 ▼a 관리자