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020 ▼a 9780438250369
035 ▼a (MiAaPQ)AAI10828209
035 ▼a (MiAaPQ)ucsf:11638
040 ▼a MiAaPQ ▼c MiAaPQ ▼d 248032
0820 ▼a 614.4
1001 ▼a Ray, Kathryn.
24510 ▼a Innovative Microbial Outcomes in Randomized Control Trials.
260 ▼a [S.l.] : ▼b University of California, San Francisco., ▼c 2018
260 1 ▼a Ann Arbor : ▼b ProQuest Dissertations & Theses, ▼c 2018
300 ▼a 76 p.
500 ▼a Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B.
500 ▼a Adviser: Thomas M. Lietman.
5021 ▼a Thesis (Ph.D.)--University of California, San Francisco, 2018.
520 ▼a Randomized Control Trials (RCTs) in infectious disease can use a clinical outcome or a microbiological surrogate outcome. While caregivers are more interested in the clinical outcome, the microbiological outcome may be far more sensitive. Here I
520 ▼a In chapter one, I design and analyze an experiment to compare community microbiome diversity estimates derived from 16s rRNA sequencing of 1) individually sequenced specimens versus 2) pooled specimens collected from a community. I then compare
520 ▼a The estimates of community level microbiome diversity from pooled samples correlated well with estimates from individual samples. Additionally, all pooled samples fell within the 95% limits of agreement. Pooling microbiome samples to estimate co
590 ▼a School code: 0034.
650 4 ▼a Epidemiology.
650 4 ▼a Public health.
690 ▼a 0766
690 ▼a 0573
71020 ▼a University of California, San Francisco. ▼b Epidemiology and Translational Science.
7730 ▼t Dissertation Abstracts International ▼g 79-12B(E).
773 ▼t Dissertation Abstract International
790 ▼a 0034
791 ▼a Ph.D.
792 ▼a 2018
793 ▼a English
85640 ▼u http://www.riss.kr/pdu/ddodLink.do?id=T14999131 ▼n KERIS
980 ▼a 201812 ▼f 2019
990 ▼a 관리자