| LDR | | 02176nmm uu200445 4500 |
| 001 | | 000000334061 |
| 005 | | 20240805175046 |
| 008 | | 181129s2018 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438250314 |
| 035 | |
▼a (MiAaPQ)AAI10827863 |
| 035 | |
▼a (MiAaPQ)ucsf:11633 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 082 | 0 |
▼a 616.99 |
| 100 | 1 |
▼a Jahangiri, Arman. |
| 245 | 10 |
▼a Cross-activating c-Met/beta1 Integrin Complex Drives Metastasis and Invasive Resistance in Cancer. |
| 260 | |
▼a [S.l.] :
▼b University of California, San Francisco.,
▼c 2018 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2018 |
| 300 | |
▼a 144 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B. |
| 500 | |
▼a Advisers: Joseph F. Costello |
| 502 | 1 |
▼a Thesis (Ph.D.)--University of California, San Francisco, 2018. |
| 520 | |
▼a The molecular underpinnings of invasion, a hallmark of cancer, have been defined in terms of individual mediators but crucial interactions between these mediators remain undefined. In xenograft models and patient specimens, we identified a c-Met |
| 520 | |
▼a Inducing c-Met/beta1 complex formation through an engineered inducible heterodimerization system promoted features crucial to overcoming stressors during metastases or antiangiogenic therapy: migration in the primary site, survival under hypoxia |
| 520 | |
▼a Complex formation promoted ligand-independent receptor activation, with integrin-linked kinase phosphorylating c-Met and crystallography revealing the c-Met/beta1 complex to maintain the high-affinity beta1 integrin conformation. Site-directed m |
| 590 | |
▼a School code: 0034. |
| 650 | 4 |
▼a Oncology. |
| 650 | 4 |
▼a Biochemistry. |
| 650 | 4 |
▼a Cellular biology. |
| 690 | |
▼a 0992 |
| 690 | |
▼a 0487 |
| 690 | |
▼a 0379 |
| 710 | 20 |
▼a University of California, San Francisco.
▼b Biomedical Sciences. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-12B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0034 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T14999084
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자 |