| LDR | | 02295nmm uu200457 4500 |
| 001 | | 000000334030 |
| 005 | | 20240805175011 |
| 008 | | 181129s2018 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438110045 |
| 035 | |
▼a (MiAaPQ)AAI10827605 |
| 035 | |
▼a (MiAaPQ)ucsd:17586 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 082 | 0 |
▼a 574 |
| 100 | 1 |
▼a Alvarez, Roberto, Jr. |
| 245 | 10 |
▼a Cardiomyocyte Cell Cycle Revealed by FUCCI. |
| 260 | |
▼a [S.l.] :
▼b University of California, San Diego.,
▼c 2018 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2018 |
| 300 | |
▼a 120 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-11(E), Section: B. |
| 500 | |
▼a Adviser: Mark A. Sussman. |
| 502 | 1 |
▼a Thesis (Ph.D.)--University of California, San Diego, 2018. |
| 520 | |
▼a Rationale: Pre-existing cardiomyocytes and resident cardiac stem cells are limited in their capacity for substantial regeneration in postnatal endogenous mammalian myocardial repair. Evidence for adult cardiomyocyte proliferation remains inconcl |
| 520 | |
▼a Objective: Authenticate fidelity of proliferative markers as indicators of de novo cardiomyogenesis and subsequently delineate the post-mitotic status of postnatal cardiomyocytes. |
| 520 | |
▼a Methods and Results: Cardiomyocyte specific FUCCI expression driven by the alpha-myosin heavy chain (alphaMHC) promoter was utilized in conjunction with traditional proliferation markers to identify cell cycle status of postnatal murine cardiomy |
| 520 | |
▼a Conclusions: Proliferation markers used to identify de novo cardiomyogenesis failed to distinguish cycling cardiomyocytes after injury. Adult cardiomyocytes upregulated cell cycle activity in response to sham injury but failed to complete regene |
| 590 | |
▼a School code: 0033. |
| 650 | 4 |
▼a Biology. |
| 650 | 4 |
▼a Cellular biology. |
| 650 | 4 |
▼a Molecular biology. |
| 690 | |
▼a 0306 |
| 690 | |
▼a 0379 |
| 690 | |
▼a 0307 |
| 710 | 20 |
▼a University of California, San Diego.
▼b Biology. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-11B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0033 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T14999048
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자 |