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020 ▼a 9780438037939
035 ▼a (MiAaPQ)AAI10827456
035 ▼a (MiAaPQ)ucla:16917
040 ▼a MiAaPQ ▼c MiAaPQ ▼d 248032
0820 ▼a 547
1001 ▼a Picazo, Elias.
24510 ▼a Enantioselective Total Syntheses of Akuammiline Alkaloids and Arynes as Building Blocks for Enantioenriched Products.
260 ▼a [S.l.] : ▼b University of California, Los Angeles., ▼c 2018
260 1 ▼a Ann Arbor : ▼b ProQuest Dissertations & Theses, ▼c 2018
300 ▼a 564 p.
500 ▼a Source: Dissertation Abstracts International, Volume: 79-10(E), Section: B.
500 ▼a Adviser: Neil K. Garg.
5021 ▼a Thesis (Ph.D.)--University of California, Los Angeles, 2018.
520 ▼a This dissertation features two projects concerning natural product synthesis and reaction development. The importance of natural product synthesis in chemistry and medicine cannot be overstated. In addition to providing a complex setting to test
520 ▼a Chapters One, Two, Three, and Four focus on an unusual variant of the Fischer indolization reaction and its application in the total synthesis of a particularly interesting class of indole alkaloids named the akuammilines. Specifically, Chapter
520 ▼a Chapters Two, Three, and Four describe enantioselective syntheses of various akuammiline alkaloids, in addition to several akuammiline alkaloid derivatives. Central to our approach was the development of modern variants of the classic Fischer in
520 ▼a Chapters Five describes an application of the distortion/interaction model to a variety of mono and disubstituted benzynes and substituted indolynes. Chapter Six is focused on the development of a facile method to synthesize stereodefined quater
590 ▼a School code: 0031.
650 4 ▼a Organic chemistry.
690 ▼a 0490
71020 ▼a University of California, Los Angeles. ▼b Chemistry 0153.
7730 ▼t Dissertation Abstracts International ▼g 79-10B(E).
773 ▼t Dissertation Abstract International
790 ▼a 0031
791 ▼a Ph.D.
792 ▼a 2018
793 ▼a English
85640 ▼u http://www.riss.kr/pdu/ddodLink.do?id=T14999029 ▼n KERIS
980 ▼a 201812 ▼f 2019
990 ▼a 관리자