| LDR | | 02051nmm uu200421 4500 |
| 001 | | 000000333989 |
| 005 | | 20240805174923 |
| 008 | | 181129s2018 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438175433 |
| 035 | |
▼a (MiAaPQ)AAI10827277 |
| 035 | |
▼a (MiAaPQ)washington:18644 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 082 | 0 |
▼a 574 |
| 100 | 1 |
▼a Iranon, Nicole Nalani. |
| 245 | 10 |
▼a Fasting Protects against Proteostasis Defects Induced by Hypoxia. |
| 260 | |
▼a [S.l.] :
▼b University of Washington.,
▼c 2018 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2018 |
| 300 | |
▼a 153 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B. |
| 500 | |
▼a Adviser: Dana Miller. |
| 502 | 1 |
▼a Thesis (Ph.D.)--University of Washington, 2018. |
| 520 | |
▼a When blood flow to various parts of the body becomes restricted, those tissues suffer from a lack of oxygen, a condition called hypoxia. Hypoxia can impair essential physiological processes and cause cellular damage and death, such as is observe |
| 520 | |
▼a I show that nutritional cues regulate the effect of hypoxia on proteostasis and that both the insulin/IGF-1 signaling (IIS) pathway and AMP-activated protein kinase (AMPK) play roles in mediating the effects of hypoxia and nutrient deprivation o |
| 520 | |
▼a Furthermore, I found a role for AMPK in regulating the response to hypoxia that depends on the nutritional status of the animal. In fed conditions AMPK promotes protein aggregation, but without food AMPK is required for fasting-induced protectio |
| 590 | |
▼a School code: 0250. |
| 650 | 4 |
▼a Biology. |
| 650 | 4 |
▼a Pathology. |
| 690 | |
▼a 0306 |
| 690 | |
▼a 0571 |
| 710 | 20 |
▼a University of Washington.
▼b Molecular and Cellular Biology. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-12B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0250 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T14999007
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자 |