| LDR | | 02317nmm uu200409 4500 |
| 001 | | 000000333938 |
| 005 | | 20240805174824 |
| 008 | | 181129s2017 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438125841 |
| 035 | |
▼a (MiAaPQ)AAI10902978 |
| 035 | |
▼a (MiAaPQ)umichrackham:001128 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 082 | 0 |
▼a 616 |
| 100 | 1 |
▼a Stewart, Megan N. |
| 245 | 10 |
▼a Positron Emission Tomography Radiochemistry: Improved Methodology and a Novel PET Imaging Agent for the Dopamine D3 Receptor. |
| 260 | |
▼a [S.l.] :
▼b University of Michigan.,
▼c 2017 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2017 |
| 300 | |
▼a 462 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B. |
| 500 | |
▼a Adviser: Peter J. Scott. |
| 502 | 1 |
▼a Thesis (Ph.D.)--University of Michigan, 2017. |
| 520 | |
▼a Positron Emission Tomography (PET) imaging is a powerful non-invasive imaging modality used to quantify biochemical processes in vivo. The work described in this thesis encompasses two aspects of PET radiochemistry: (1) the development of new ch |
| 520 | |
▼a (1) As a way to simplify FDA mandated quality control and residual solvent analysis prior to the release of PET radiopharmaceuticals we sought to apply the principles of green chemistry to 18F-radiochemistry. Green radiochemistry in late-stage s |
| 520 | |
▼a (2) Dopamine is a monoamine neurotransmitter in the Central Nervous System (CNS), and its signaling is mediated by pre-synaptic and post-synaptic dopamine receptors. These are D1-like (D1 and D5) and D2-like (D2, D3, D4) receptors, which are G p |
| 520 | |
▼a The synthesis and initial evaluation of a series of new carbon-11 and fluorine-18 PET radioligands for the D3 receptor is described. These radioligands are based on known ligands with good selectivity for the D3 receptor (pramipexole and BP897). |
| 590 | |
▼a School code: 0127. |
| 650 | 4 |
▼a Medical imaging. |
| 690 | |
▼a 0574 |
| 710 | 20 |
▼a University of Michigan.
▼b Medicinal Chemistry. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-12B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0127 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2017 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T15000486
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자 |