| LDR | | 02576nmm uu200421 4500 |
| 001 | | 000000333878 |
| 005 | | 20240805174716 |
| 008 | | 181129s2017 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438097797 |
| 035 | |
▼a (MiAaPQ)AAI10901835 |
| 035 | |
▼a (MiAaPQ)OhioLINK:osu1510240057079338 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 082 | 0 |
▼a 616 |
| 100 | 1 |
▼a Todd, Levi. |
| 245 | 14 |
▼a The Signaling Pathways that Regulate the Proliferative and Neurogenic Capacity of Muller glia. |
| 260 | |
▼a [S.l.] :
▼b The Ohio State University.,
▼c 2017 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2017 |
| 300 | |
▼a 178 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B. |
| 500 | |
▼a Adviser: Andrew Fischer. |
| 502 | 1 |
▼a Thesis (Ph.D.)--The Ohio State University, 2017. |
| 520 | |
▼a Eye diseases that result in blindness are often caused by the death of retinal neurons. Muller glia are the major glial support cells in the retina and possess the potential to reprogram into neurogenic progenitor cells. In the fish, Muller glia |
| 520 | |
▼a The first chapter focuses on how Hedgehog signaling stimulates Muller glia to reprogram into proliferating progenitors in the chick retina. We show that the Hedgehog-pathway components are up-regulated in damaged retinas when MGPCs are known to |
| 520 | |
▼a The second chapter examines how Jak/Stat signaling impacts the regenerative capacity of the avian retina. We find that Jak/Stat signaling is rapidly activated in Muller glia in response to retinal damage. We also show that inhibition of the Jak/ |
| 520 | |
▼a The third chapter analyzes how Retinoic acid (RA)-signaling regulates the proliferative and neurogenic potential of avian Muller glia. We find that the RA-component CRABP is specifically up-regulated by Muller glia in response to retinal injury. |
| 520 | |
▼a Collectively, the work described in this dissertation represents significant advances in understanding the mechanisms underlying retinal regeneration in the avian retina. Each chapter describes novel data regarding the signaling pathways that re |
| 590 | |
▼a School code: 0168. |
| 650 | 4 |
▼a Neurosciences. |
| 690 | |
▼a 0317 |
| 710 | 20 |
▼a The Ohio State University.
▼b Neuroscience Graduate Studies Program. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-12B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0168 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2017 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T15000282
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자 |