| LDR | | 02298nmm uu200409 4500 |
| 001 | | 000000333825 |
| 005 | | 20240805174617 |
| 008 | | 181129s2018 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438126879 |
| 035 | |
▼a (MiAaPQ)AAI10903081 |
| 035 | |
▼a (MiAaPQ)umichrackham:001188 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 082 | 0 |
▼a 574 |
| 100 | 1 |
▼a Chun, Sang Young. |
| 245 | 10 |
▼a Development and Application of Next-Generation Sequencing Methods to Profile Cellular Translational Dynamics. |
| 260 | |
▼a [S.l.] :
▼b University of Michigan.,
▼c 2018 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2018 |
| 300 | |
▼a 166 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B. |
| 500 | |
▼a Adviser: Ryan Edward Mills. |
| 502 | 1 |
▼a Thesis (Ph.D.)--University of Michigan, 2018. |
| 520 | |
▼a The transmission of genetic information from the transcription of DNA to RNA and the subsequent translation of RNA into protein is often abstracted into a linear process. However, as methods and technologies to measure the genomic, transcriptomi |
| 520 | |
▼a In the first chapter, I survey the development and application of next-generation sequencing methods for the profiling and computational analysis of translation and translational dynamics. In the second chapter of this thesis, I present SPECtre, |
| 520 | |
▼a In the third chapter, I describe the application of SPECtre to identify the translation of upstream-initiated open-reading frames that may regulate differentiation in a neuron-like cell model. uORFs are transcripts that result from the initiatio |
| 520 | |
▼a Finally, in the fourth chapter, I outline a strategy using our coherence-based translational scoring algorithm to profile ribosomal engagement over chimeric gene fusion breakpoints in prostate cancer. Here, known breakpoints from current annotat |
| 590 | |
▼a School code: 0127. |
| 650 | 4 |
▼a Bioinformatics. |
| 690 | |
▼a 0715 |
| 710 | 20 |
▼a University of Michigan.
▼b Bioinformatics. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-12B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0127 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T15000576
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자 |