| LDR | | 03280nmm uu200457 4500 |
| 001 | | 000000333818 |
| 005 | | 20240805174609 |
| 008 | | 181129s2018 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438126787 |
| 035 | |
▼a (MiAaPQ)AAI10903072 |
| 035 | |
▼a (MiAaPQ)umichrackham:001268 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 082 | 0 |
▼a 614.4 |
| 100 | 1 |
▼a Flannagan, Kerry Susan. |
| 245 | 10 |
▼a Polyunsaturated Fatty Acids and Early-Life Cardiometabolic Disease Risk. |
| 260 | |
▼a [S.l.] :
▼b University of Michigan.,
▼c 2018 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2018 |
| 300 | |
▼a 199 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B. |
| 500 | |
▼a Adviser: Eduardo Villamor. |
| 502 | 1 |
▼a Thesis (Ph.D.)--University of Michigan, 2018. |
| 520 | |
▼a Background: Polyunsaturated fatty acid (PUFA) intake is low throughout Latin America, but sociodemographic patterning and dietary sources of PUFA status in the region are poorly characterized. PUFA may be related to the development of early-life |
| 520 | |
▼a Objectives: To identify sociodemographic, anthropometric, and dietary correlates of PUFA status in Mesoamerica (aim 1), and to examine the relations of n-3 and n-6 PUFA with metabolic syndrome (MetS) (aim 2) and development of adiposity in child |
| 520 | |
▼a Methods: Aims 1 and 2 were completed using data from the Nine Mesoamerican Countries Metabolic Syndrome (NiMeCoMeS) study, a cross-sectional investigation of school-age children and their parents from the capital cities of Guatemala, Honduras, E |
| 520 | |
▼a In aim 1, we assessed correlates of adipose tissue PUFA biomarkers by estimating percent mean differences in each PUFA between levels of predictors using multivariable-adjusted linear regression models. |
| 520 | |
▼a In aim 2, we examined associations between PUFA and MetS in parents, and between PUFA and a continuous metabolic risk score in children. We estimated prevalence ratios of MetS in adults and mean differences in metabolic score in children across |
| 520 | |
▼a Aim 3 was conducted in the context of a cohort of children from Santiago, Chile who were recruited in infancy and followed through adolescence. PUFA were quantified in serum at 5 and 10 y of age. Body mass index (BMI) was measured at 5, 10, and |
| 520 | |
▼a Results: Country of origin was the strongest predictor of all essential and long-chain PUFA biomarkers. The type of cooking oil used in the home was the strongest dietary correlate of PUFA status. Among adults, MetS prevalence was inversely asso |
| 520 | |
▼a Conclusions and significance: PUFA status within Latin America is heterogeneous and is related to the type of vegetable oil used for cooking. ALA is inversely associated with MetS among adults but long-chain n-3 PUFA do not appear to be protecti |
| 590 | |
▼a School code: 0127. |
| 650 | 4 |
▼a Epidemiology. |
| 690 | |
▼a 0766 |
| 710 | 20 |
▼a University of Michigan.
▼b Epidemiological Science. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-12B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0127 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T15000568
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자 |