| LDR | | 01735nmm uu200385 4500 |
| 001 | | 000000333794 |
| 005 | | 20240805174542 |
| 008 | | 181129s2017 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438098671 |
| 035 | |
▼a (MiAaPQ)AAI10901928 |
| 035 | |
▼a (MiAaPQ)OhioLINK:osu1511778914988389 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 082 | 0 |
▼a 615 |
| 100 | 1 |
▼a Luo, Xiao. |
| 245 | 10 |
▼a Development of Lipid-like Nanoparticles for mRNA Delivery. |
| 260 | |
▼a [S.l.] :
▼b The Ohio State University.,
▼c 2017 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2017 |
| 300 | |
▼a 191 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B. |
| 500 | |
▼a Adviser: Yizhou Dong. |
| 502 | 1 |
▼a Thesis (Ph.D.)--The Ohio State University, 2017. |
| 520 | |
▼a Messenger RNA (mRNA) as an emerging new drug class is being extensively investigated in the fields of cancer immunotherapy, infectious disease vaccines, protein replacement therapy, and regenerative medicine. The inherent nature of mRNA renders |
| 520 | |
▼a The objective of this dissertation is to improve mRNA translation and develop lipid-like nanoparticles (LLNs) for the safe and efficient delivery of mRNA. In chapter 2, we constructed two sets of chemically modified mRNAs encoding firefly Lucife |
| 590 | |
▼a School code: 0168. |
| 650 | 4 |
▼a Pharmacology. |
| 690 | |
▼a 0419 |
| 710 | 20 |
▼a The Ohio State University.
▼b Pharmaceutical Sciences. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-12B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0168 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2017 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T15000328
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자 |