| LDR | | 02753nmm uu200433 4500 |
| 001 | | 000000333613 |
| 005 | | 20240805173351 |
| 008 | | 181129s2018 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438170940 |
| 035 | |
▼a (MiAaPQ)AAI10750169 |
| 035 | |
▼a (MiAaPQ)nyu:13225 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 082 | 0 |
▼a 616 |
| 100 | 1 |
▼a Wilson, Christopher D. |
| 245 | 10 |
▼a Rapid Encoding of Odor Identity via a Primacy Code. |
| 260 | |
▼a [S.l.] :
▼b New York University.,
▼c 2018 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2018 |
| 300 | |
▼a 148 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B. |
| 500 | |
▼a Adviser: Dmitry Rinberg. |
| 502 | 1 |
▼a Thesis (Ph.D.)--New York University, 2018. |
| 520 | |
▼a Stimulus variability presents a computational challenge for sensory systems. In the olfactory system, shifts in odor concentration represent a significant source of variability. This thesis examines a potential computational principle underlying |
| 520 | |
▼a Primacy coding represents odor identity in only a small number of maximally sensitive sensors for a given odor. By isolating these primary features from the overall population of responses, it has been proposed that a large degree of invariance |
| 520 | |
▼a We hypothesize that primary set responds with the lowest latency, and that the olfactory system uses time to recover this invariant set from the overall pattern of activity. By using solely a small number of earliest responses in a sniff, the sy |
| 520 | |
▼a To test whether early odor-evoked activity is sufficient for odor identification, we employed a novel behavioral paradigm named "optogenetic masking". Mice were trained to discriminate between odors across a range of concentrations. On a small n |
| 520 | |
▼a To study whether early odor-evoked neural activity is actually a good source of odor identity information, we employed extracellular electrophysiology and advanced olfactometery. In recording from putative mitral/tufted cells in the olfactory bu |
| 520 | |
▼a Finally, I undertook an exploratory project to determine the transfer function of the olfactory bulb using patterned optogenetic stimulation. Using this technology, we hope to establish an input-output model of the OB that will allow us to evalu |
| 590 | |
▼a School code: 0146. |
| 650 | 4 |
▼a Neurosciences. |
| 690 | |
▼a 0317 |
| 710 | 20 |
▼a New York University.
▼b Basic Medical Science. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-12B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0146 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T14997087
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자 |