| LDR | | 02447nmm uu200421 4500 |
| 001 | | 000000333604 |
| 005 | | 20240805173341 |
| 008 | | 181129s2018 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438036123 |
| 035 | |
▼a (MiAaPQ)AAI10749925 |
| 035 | |
▼a (MiAaPQ)upenngdas:13138 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 082 | 0 |
▼a 574 |
| 100 | 1 |
▼a Emmer, Kristel Lucie. |
| 245 | 10 |
▼a Induction of Antibodies to HIV-1 Envelope Using Simian Adenovirus Vaccines. |
| 260 | |
▼a [S.l.] :
▼b University of Pennsylvania.,
▼c 2018 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2018 |
| 300 | |
▼a 143 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-10(E), Section: B. |
| 500 | |
▼a Adviser: Hildegund C. Ertl. |
| 502 | 1 |
▼a Thesis (Ph.D.)--University of Pennsylvania, 2018. |
| 520 | |
▼a Human immunodeficiency virus type 1 (HIV-1) has infected 76 million people since the beginning of the epidemic. The first evidence that an HIV-1 vaccine could prevent infection in humans was provided in the RV144 vaccine efficacy trial. RV144 de |
| 520 | |
▼a Several approaches can be employed to improve upon vaccination strategies: heterologous prime-boost regimens, immunogen design, and alternative adjuvants. To enhance Env-specific antibodies, I tested simian-derived adenovirus (SAdV) vectors expr |
| 520 | |
▼a It has been suggested that a vaccine designed to elicit greater V2-specific antibody responses than that seen in the RV144 trial may be more effective at preventing HIV-1 infection. The variable 1 and 2 (V1/V2) region of Env has been grafted ont |
| 520 | |
▼a In the third study, I tested calcium phosphate (CaP) as an adjuvant to a recombinant Env protein compared to alum adjuvant. Alum, the most commonly used adjuvant, induces suboptimal immune responses. CaP has demonstrated preferential immune resp |
| 520 | |
▼a These studies demonstrate SAdV vectors as advantageous vaccine vector platforms and that novel immunogen design can improve HIV-1 vaccines. |
| 590 | |
▼a School code: 0175. |
| 650 | 4 |
▼a Molecular biology. |
| 690 | |
▼a 0307 |
| 710 | 20 |
▼a University of Pennsylvania.
▼b Cell and Molecular Biology. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-10B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0175 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T14997078
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자 |