| LDR | | 02053nmm uu200421 4500 |
| 001 | | 000000333461 |
| 005 | | 20240805173055 |
| 008 | | 181129s2018 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438117174 |
| 035 | |
▼a (MiAaPQ)AAI10821929 |
| 035 | |
▼a (MiAaPQ)northwestern:14177 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 082 | 0 |
▼a 575 |
| 100 | 1 |
▼a Gorsic, Lidija Kristina. |
| 245 | 10 |
▼a Characterization of Rare Genetic Variation in Polycystic Ovary Syndrome. |
| 260 | |
▼a [S.l.] :
▼b Northwestern University.,
▼c 2018 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2018 |
| 300 | |
▼a 160 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-11(E), Section: B. |
| 500 | |
▼a Advisers: Ji-Yong Julie Kim |
| 502 | 1 |
▼a Thesis (Ph.D.)--Northwestern University, 2018. |
| 520 | |
▼a Polycystic ovary syndrome (PCOS) is a common endocrine disorder affecting approximately 1 in 10 reproductive-age women and remains the leading cause of female factor infertility among women of childbearing age. PCOS presents with features of hyp |
| 520 | |
▼a Two of the 11 panel genes included anti-Mullerian hormone ( AMH) and its specific type II receptor (AMHR2). Women affected with PCOS often have elevated levels of AMH. In the ovary AMH inhibits follicle maturation, thus the elevated AMH levels s |
| 520 | |
▼a Given that PCOS is a complex disorder with a heterogeneous presentation, several genes and pathways likely lead to various PCOS phenotypes. Analyses of targeted resequencing data also identified predicted deleterious missense variants, specific |
| 590 | |
▼a School code: 0163. |
| 650 | 4 |
▼a Genetics. |
| 650 | 4 |
▼a Endocrinology. |
| 690 | |
▼a 0369 |
| 690 | |
▼a 0409 |
| 710 | 20 |
▼a Northwestern University.
▼b Life Sciences. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-11B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0163 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T14998432
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자 |