| LDR | | 02900nmm uu200433 4500 |
| 001 | | 000000333400 |
| 005 | | 20240805172946 |
| 008 | | 181129s2018 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438048140 |
| 035 | |
▼a (MiAaPQ)AAI10816957 |
| 035 | |
▼a (MiAaPQ)buffalo:15704 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 082 | 0 |
▼a 614.4 |
| 100 | 1 |
▼a Jacobs, David Matthew. |
| 245 | 10 |
▼a Relationships Between Bacteria, Exacerbations, and Hospitalizations in Chronic Obstructive Pulmonary Disease. |
| 260 | |
▼a [S.l.] :
▼b State University of New York at Buffalo.,
▼c 2018 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2018 |
| 300 | |
▼a 132 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-10(E), Section: B. |
| 500 | |
▼a Adviser: Heather M. Ochs-Balcom. |
| 502 | 1 |
▼a Thesis (Ph.D.)--State University of New York at Buffalo, 2018. |
| 520 | |
▼a Bacteria within the lower respiratory tract plays a critical role in the clinical course and pathogenesis of chronic obstructive pulmonary disease (COPD). Evidence suggests that acute exacerbations are attributable to bacteria, and these exacerb |
| 520 | |
▼a The first part of this dissertation investigates the clinical impact of P. aeruginosa isolation in an outpatient COPD cohort. P. aeruginosa is an important pathogen in choric airway diseases including cystic fibrosis and bronchiectasis, signifi |
| 520 | |
▼a Therefore, this aim investigated the association of P. aeruginosa isolation with long-term mortality and patient outcomes (exacerbations and hospitalizations) in a sample of U.S. veterans with COPD (n=181). After adjustment for age and pulmonar |
| 520 | |
▼a The second part of the dissertation investigated bacterial colonization patterns and interactions among the four primary bacterial pathogens. Interspecies bacterial interactions can alter the composition of a microbial community and potentially |
| 520 | |
▼a This aim evaluated the prevalence of bacterial colonization and determined species-specific interactions using sputum cultures collected at monthly visits in a sample of veterans with COPD over a 20 year period (n=8,843 clinic visits). Our findi |
| 520 | |
▼a For our third aim, we shifted to a health-services focus in order to further understand the causes and factors related to 30-day readmission for an acute exacerbation of COPD. This was prompted based on the recent inclusion of COPD discharges as |
| 590 | |
▼a School code: 0656. |
| 650 | 4 |
▼a Epidemiology. |
| 690 | |
▼a 0766 |
| 710 | 20 |
▼a State University of New York at Buffalo.
▼b Epidemiology and Environmental Health. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-10B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0656 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T14998306
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자 |