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008181129s2018 |||||||||||||||||c||eng d
020 ▼a 9780438125148
035 ▼a (MiAaPQ)AAI10816936
035 ▼a (MiAaPQ)northwestern:14145
040 ▼a MiAaPQ ▼c MiAaPQ ▼d 248032
0820 ▼a 621
1001 ▼a Ma, Dan. ▼0 (orcid)0000-0001-9701-2750
24510 ▼a Investigation of Polymer Conjugated Helix Bundle Peptides to Design Micellar Nanocarriers with Tunable Size and Stability using Molecular Dynamics.
260 ▼a [S.l.] : ▼b Northwestern University., ▼c 2018
260 1 ▼a Ann Arbor : ▼b ProQuest Dissertations & Theses, ▼c 2018
300 ▼a 131 p.
500 ▼a Source: Dissertation Abstracts International, Volume: 79-11(E), Section: B.
500 ▼a Adviser: Sinan Keten.
5021 ▼a Thesis (Ph.D.)--Northwestern University, 2018.
520 ▼a Hybrid polymer-peptide conjugates are receiving increasing attention as a promising class of biomaterials. Polymer conjugated coiled-coil peptides are a new addition to these designer macromolecules. Even though a variety of experiments and comp
520 ▼a Building on these findings, we focus on a recent design that has utilized end-conjugation of alkyl chains to 3-helix coiled-coils to achieve amphiphilicity, combined with the side-chain conjugation of polyethylene glycol (PEG) to tune micelle si
520 ▼a Homomeric micelles with tunable size, shape and stability have been extensively studied for biomedical applications such as drug carriers. However, designing the local valency and self-assembled morphology of nanophase-separated multicomponent m
590 ▼a School code: 0163.
650 4 ▼a Mechanical engineering.
690 ▼a 0548
71020 ▼a Northwestern University. ▼b Mechanical Engineering.
7730 ▼t Dissertation Abstracts International ▼g 79-11B(E).
773 ▼t Dissertation Abstract International
790 ▼a 0163
791 ▼a Ph.D.
792 ▼a 2018
793 ▼a English
85640 ▼u http://www.riss.kr/pdu/ddodLink.do?id=T14998302 ▼n KERIS
980 ▼a 201812 ▼f 2019
990 ▼a 관리자