| LDR | | 02388nmm uu200421 4500 |
| 001 | | 000000333309 |
| 005 | | 20240805172804 |
| 008 | | 181129s2018 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438168213 |
| 035 | |
▼a (MiAaPQ)AAI10816081 |
| 035 | |
▼a (MiAaPQ)ucsd:17409 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 082 | 0 |
▼a 574 |
| 100 | 1 |
▼a Huang, Justin Kwang-Lay. |
| 245 | 10 |
▼a Applications of Network Propagation for the Discovery of Candidate Genes in Human Disease. |
| 260 | |
▼a [S.l.] :
▼b University of California, San Diego.,
▼c 2018 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2018 |
| 300 | |
▼a 138 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B. |
| 500 | |
▼a Includes supplementary digital materials. |
| 500 | |
▼a Adviser: Trey Ideker. |
| 502 | 1 |
▼a Thesis (Ph.D.)--University of California, San Diego, 2018. |
| 520 | |
▼a The molecular system of the cell can be represented as a network with genes or proteins represented as the nodes and the various types of interactions between these proteins represented as the edges. This dissertation explores both the benefits |
| 520 | |
▼a First, I present NSD1, a histone methyltransferase, that when mutated, confers improved survival for HPV-negative head and neck squamous cell cancer (HNSCC) patients. This project describes a standard approach for the discovery and validation of |
| 520 | |
▼a In contrast to the NSD1 results, many cancer cohorts cannot be subtyped easily by the mutation status of a single, or small number of genes due to the heterogeneity of tumor genomes. Therefore, I developed a software package implementing an algo |
| 520 | |
▼a In the final chapter of my thesis, I created a framework to evaluate molecular networks on their capacity to recover known disease-associated gene sets via network propagation. Given the number and diversity of molecular networks available, this |
| 590 | |
▼a School code: 0033. |
| 650 | 4 |
▼a Bioinformatics. |
| 690 | |
▼a 0715 |
| 710 | 20 |
▼a University of California, San Diego.
▼b Bioinformatics and Systems Biology. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-12B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0033 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T14998220
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자 |