MARC보기
LDR02388nmm uu200421 4500
001000000333309
00520240805172804
008181129s2018 |||||||||||||||||c||eng d
020 ▼a 9780438168213
035 ▼a (MiAaPQ)AAI10816081
035 ▼a (MiAaPQ)ucsd:17409
040 ▼a MiAaPQ ▼c MiAaPQ ▼d 248032
0820 ▼a 574
1001 ▼a Huang, Justin Kwang-Lay.
24510 ▼a Applications of Network Propagation for the Discovery of Candidate Genes in Human Disease.
260 ▼a [S.l.] : ▼b University of California, San Diego., ▼c 2018
260 1 ▼a Ann Arbor : ▼b ProQuest Dissertations & Theses, ▼c 2018
300 ▼a 138 p.
500 ▼a Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B.
500 ▼a Includes supplementary digital materials.
500 ▼a Adviser: Trey Ideker.
5021 ▼a Thesis (Ph.D.)--University of California, San Diego, 2018.
520 ▼a The molecular system of the cell can be represented as a network with genes or proteins represented as the nodes and the various types of interactions between these proteins represented as the edges. This dissertation explores both the benefits
520 ▼a First, I present NSD1, a histone methyltransferase, that when mutated, confers improved survival for HPV-negative head and neck squamous cell cancer (HNSCC) patients. This project describes a standard approach for the discovery and validation of
520 ▼a In contrast to the NSD1 results, many cancer cohorts cannot be subtyped easily by the mutation status of a single, or small number of genes due to the heterogeneity of tumor genomes. Therefore, I developed a software package implementing an algo
520 ▼a In the final chapter of my thesis, I created a framework to evaluate molecular networks on their capacity to recover known disease-associated gene sets via network propagation. Given the number and diversity of molecular networks available, this
590 ▼a School code: 0033.
650 4 ▼a Bioinformatics.
690 ▼a 0715
71020 ▼a University of California, San Diego. ▼b Bioinformatics and Systems Biology.
7730 ▼t Dissertation Abstracts International ▼g 79-12B(E).
773 ▼t Dissertation Abstract International
790 ▼a 0033
791 ▼a Ph.D.
792 ▼a 2018
793 ▼a English
85640 ▼u http://www.riss.kr/pdu/ddodLink.do?id=T14998220 ▼n KERIS
980 ▼a 201812 ▼f 2019
990 ▼a 관리자