| LDR | | 02081nmm uu200397 4500 |
| 001 | | 000000333284 |
| 005 | | 20240805172736 |
| 008 | | 181129s2018 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438088344 |
| 035 | |
▼a (MiAaPQ)AAI10815742 |
| 035 | |
▼a (MiAaPQ)uchicago:14382 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 082 | 0 |
▼a 576 |
| 100 | 1 |
▼a Sampedro, Georgia Rafaella.
▼0 (orcid)0000-0002-3755-6171 |
| 245 | 10 |
▼a Staphylococcus Aureus alpha-toxin Damages the Tissue Microenvironment during Skin and Soft Tissue Infection. |
| 260 | |
▼a [S.l.] :
▼b The University of Chicago.,
▼c 2018 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2018 |
| 300 | |
▼a 140 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-11(E), Section: B. |
| 500 | |
▼a Adviser: Juliane Bubeck Wardenburg. |
| 502 | 1 |
▼a Thesis (Ph.D.)--The University of Chicago, 2018. |
| 520 | |
▼a Staphylococcus aureus is a pathobiont that can cause a range of mild to life-threatening infection in otherwise healthy individuals. While S. aureus disease has a broad tissue tropism, the most common site for both colonization and infection is |
| 520 | |
▼a To investigate whether there is a mechanistic link between alpha-toxin expression and the severity of S. aureus reinfection patterns, we developed a mouse model of recurrent S. aureus SSTI mouse model. Using an isogenic Hla mutant in this model |
| 520 | |
▼a Probing into mechanism, we identified Hla-mediated injury to cutaneous resident innate-like T cells as the cellular gatekeeper of S. aureus SSTI infection outcomes. alpha-Toxin kills both neighboring and distant epidermal T cells adjacent to th |
| 590 | |
▼a School code: 0330. |
| 650 | 4 |
▼a Microbiology. |
| 690 | |
▼a 0410 |
| 710 | 20 |
▼a The University of Chicago.
▼b Microbiology. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-11B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0330 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T14998194
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자 |