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020 ▼a 9780438116528
035 ▼a (MiAaPQ)AAI10815237
035 ▼a (MiAaPQ)northwestern:14116
040 ▼a MiAaPQ ▼c MiAaPQ ▼d 248032
0820 ▼a 530
1001 ▼a Zhang, Di.
24510 ▼a Development of Spectroscopic Microscopy to Quantify Nanoarchitectural Changes in Biological Cells.
260 ▼a [S.l.] : ▼b Northwestern University., ▼c 2018
260 1 ▼a Ann Arbor : ▼b ProQuest Dissertations & Theses, ▼c 2018
300 ▼a 119 p.
500 ▼a Source: Dissertation Abstracts International, Volume: 79-11(E), Section: B.
500 ▼a Adviser: Vadim Backman.
5021 ▼a Thesis (Ph.D.)--Northwestern University, 2018.
520 ▼a Cancer is the second leading cause of human deaths in the United States. Detection of early-stage cancer has been widely recognized as one of the most critical factors to successfully treat cancer and reduce mortality. Current gold standards for
520 ▼a Facilitated by three-dimensional, full-vector finite-difference time-domain (FDTD) computational solutions of Maxwell's equations, our group has developed a novel optical microscopy technique, Partial Wave Spectroscopic (PWS) microscopy, that ca
520 ▼a Despite the success of PWS, it made simple assumptions about the model of cells and instrument. For example, it assumes the cell has flat surfaces and the microscope has an illumination NA of 0. Additionally, the effect of biological staining on
520 ▼a In this dissertation, we expand the theory to include more realistic models of cells and instrument and validate rigorously via FDTD simulations. The results from these theoretical developments will provide essential information to optimize PWS
590 ▼a School code: 0163.
650 4 ▼a Computational physics.
650 4 ▼a Biomedical engineering.
650 4 ▼a Medical imaging.
690 ▼a 0216
690 ▼a 0541
690 ▼a 0574
71020 ▼a Northwestern University. ▼b Biomedical Engineering.
7730 ▼t Dissertation Abstracts International ▼g 79-11B(E).
773 ▼t Dissertation Abstract International
790 ▼a 0163
791 ▼a Ph.D.
792 ▼a 2018
793 ▼a English
85640 ▼u http://www.riss.kr/pdu/ddodLink.do?id=T14998162 ▼n KERIS
980 ▼a 201812 ▼f 2019
990 ▼a 관리자