| LDR | | 02042nmm uu200397 4500 |
| 001 | | 000000333179 |
| 005 | | 20240805172339 |
| 008 | | 181129s2018 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438116313 |
| 035 | |
▼a (MiAaPQ)AAI10813718 |
| 035 | |
▼a (MiAaPQ)northwestern:14108 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 082 | 0 |
▼a 576 |
| 100 | 1 |
▼a Gavin, Hannah Elizabeth.
▼0 (orcid)0000-0001-8080-7485 |
| 245 | 10 |
▼a Function of Discrete MARTX Toxin Domains in Vibrio vulnificus Intragastric Pathogenesis. |
| 260 | |
▼a [S.l.] :
▼b Northwestern University.,
▼c 2018 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2018 |
| 300 | |
▼a 238 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-11(E), Section: B. |
| 500 | |
▼a Adviser: Karla JF Satchell. |
| 502 | 1 |
▼a Thesis (Ph.D.)--Northwestern University, 2018. |
| 520 | |
▼a In 2015, the United States Department of Agriculture (USDA) reported that 1 in 6 Americans fall ill with a foodborne infection annually, resulting in more than 3000 fatalities and an estimated $15 billion in economic burden due to combine |
| 520 | |
▼a This study investigates the pathogenic mechanisms of V. vulnificus as mediated by its primary virulence factor, the Multifunctional Autoprocessing Repeats-in-Toxins (MARTX) toxin. The MARTX toxin, product of the rtxA1 gene, has been identified |
| 520 | |
▼a We also investigate roles for individual effector domains within the larger repertoire. Each of the five investigated MARTX effector domains exhibit functional redundancy in the ability to disrupt phagocytic activity and intestinal barrier integ |
| 590 | |
▼a School code: 0163. |
| 650 | 4 |
▼a Microbiology. |
| 690 | |
▼a 0410 |
| 710 | 20 |
▼a Northwestern University.
▼b Life Sciences. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-11B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0163 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T14998083
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자 |