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020 ▼a 9780438100329
035 ▼a (MiAaPQ)AAI10812798
035 ▼a (MiAaPQ)ku:15848
040 ▼a MiAaPQ ▼c MiAaPQ ▼d 248032
0820 ▼a 615
1001 ▼a Charaschanya, Manwika. ▼0 (orcid)0000-0002-2773-240X
24510 ▼a Advances in Heterocyclic Synthesis through Ring Expansions and Flow Chemistry.
260 ▼a [S.l.] : ▼b University of Kansas., ▼c 2018
260 1 ▼a Ann Arbor : ▼b ProQuest Dissertations & Theses, ▼c 2018
300 ▼a 430 p.
500 ▼a Source: Dissertation Abstracts International, Volume: 79-11(E), Section: B.
500 ▼a Adviser: Thomas Prisinzano.
5021 ▼a Thesis (Ph.D.)--University of Kansas, 2018.
520 ▼a This dissertation comprises three chapters, which focus on the development of new synthetic methodologies and the construction of a screening collection.
520 ▼a An Application of the Schmidt Reaction: Construction of an Azasteroid Library. Ring expansion chemistry is a powerful way of introducing a heteroatom substituent into carbocyclic frameworks. However, such reactions are limited by the tendency of
520 ▼a New Variations of the Schmidt Reaction: A strong hydrogen-bond-donating solvent, hexafluoro-2-propanol (HFIP), was found improve the intermolecular reaction of ketones with trimethylsilyl azide and hydroxyalkyl azides. This study prompted the hy
520 ▼a Enabling Chemistry Technologies: High-Temperature and High-Pressure Continuous Flow Chemistry. The synthetic applications of a high-temperature and high-pressure flow reactor were investigated. The Gould-Jacobs reaction, nucleophilic aromatic su
590 ▼a School code: 0099.
650 4 ▼a Pharmaceutical sciences.
650 4 ▼a Chemistry.
690 ▼a 0572
690 ▼a 0485
71020 ▼a University of Kansas. ▼b Medicinal Chemistry.
7730 ▼t Dissertation Abstracts International ▼g 79-11B(E).
773 ▼t Dissertation Abstract International
790 ▼a 0099
791 ▼a Ph.D.
792 ▼a 2018
793 ▼a English
85640 ▼u http://www.riss.kr/pdu/ddodLink.do?id=T14998040 ▼n KERIS
980 ▼a 201812 ▼f 2019
990 ▼a 관리자