| LDR | | 02330nmm uu200433 4500 |
| 001 | | 000000333010 |
| 005 | | 20240805172022 |
| 008 | | 181129s2018 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438116092 |
| 035 | |
▼a (MiAaPQ)AAI10793104 |
| 035 | |
▼a (MiAaPQ)northwestern:14083 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 082 | 0 |
▼a 574 |
| 100 | 1 |
▼a Ventrella, Rosa. |
| 245 | 10 |
▼a Molecular Organization of EphA2 Cell-Cell Communication Complexes in Human Keratinocytes. |
| 260 | |
▼a [S.l.] :
▼b Northwestern University.,
▼c 2018 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2018 |
| 300 | |
▼a 183 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-11(E), Section: B. |
| 500 | |
▼a Adviser: Spiro Getsios. |
| 502 | 1 |
▼a Thesis (Ph.D.)--Northwestern University, 2018. |
| 520 | |
▼a Erythropoietin-producing human hepatocellular (Eph) receptors and their corresponding ephrin ligands are asymmetrically expressed at cell-cell contacts allowing for bidirectional signaling with forward signaling through the receptor expressing c |
| 520 | |
▼a Ephrin-A1 contains a glycosylphosphatidylinositol (GPI)-linked tail, which targets this ligand to specific membrane microdomains known as lipid rafts. Lipid raft domains are important for regulating the distribution of membrane proteins and are |
| 520 | |
▼a In order to address these hypotheses, we used a combination of biochemical and imaging approaches to study the molecular organization of ephrin-A1 and EphA2 signaling complexes in a primary human keratinocyte culture model. We provide evidence t |
| 520 | |
▼a Collectively, these studies highlight a key role for the EphA2 TMD and its association with lipid rafts in modulating downstream signaling. Our data highlight the importance of EphA2 localization to lipid raft domains at cell-cell contacts in co |
| 590 | |
▼a School code: 0163. |
| 650 | 4 |
▼a Cellular biology. |
| 650 | 4 |
▼a Molecular biology. |
| 690 | |
▼a 0379 |
| 690 | |
▼a 0307 |
| 710 | 20 |
▼a Northwestern University.
▼b Dermatology. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-11B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0163 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T14997740
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자 |