| LDR | | 02220nmm uu200457 4500 |
| 001 | | 000000332489 |
| 005 | | 20240805170902 |
| 008 | | 181129s2018 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438031364 |
| 035 | |
▼a (MiAaPQ)AAI10787455 |
| 035 | |
▼a (MiAaPQ)umn:19075 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 082 | 0 |
▼a 575 |
| 100 | 1 |
▼a Harding, Taylor Stiver. |
| 245 | 10 |
▼a Pre-Clinical Strategies to Overcome Drug-Resistant Multiple Myeloma: Predictive Transcriptomics and Targeting the Myeloma Epigenome. |
| 260 | |
▼a [S.l.] :
▼b University of Minnesota.,
▼c 2018 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2018 |
| 300 | |
▼a 179 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-10(E), Section: B. |
| 500 | |
▼a Includes supplementary digital materials. |
| 500 | |
▼a Adviser: Brian Van Ness. |
| 502 | 1 |
▼a Thesis (Ph.D.)--University of Minnesota, 2018. |
| 520 | |
▼a Multiple myeloma remains an incurable hematological malignancy due to the failure of standard-of-care therapies to broadly target a genetically heterogeneous disease and an inability overcome inevitable drug-resistant relapse. This dissertation |
| 520 | |
▼a First, our goal was to develop a gene expression signature that predicts response specific to proteasome inhibitor (PI) treatment in MM. Using a well-characterized panel of human myeloma cell lines (HMCLs) representing the biological and genetic |
| 520 | |
▼a Epigenetic abnormalities are abundantly present in multiple myeloma and accumulating evidence suggests that the histone methyltransferase EZH2 is aberrantly active in MM. We tested the efficacy of EZH2 specific inhibitors in a large panel of hum |
| 590 | |
▼a School code: 0130. |
| 650 | 4 |
▼a Genetics. |
| 650 | 4 |
▼a Molecular biology. |
| 650 | 4 |
▼a Bioinformatics. |
| 690 | |
▼a 0369 |
| 690 | |
▼a 0307 |
| 690 | |
▼a 0715 |
| 710 | 20 |
▼a University of Minnesota.
▼b Biological Science. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-10B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0130 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T14997397
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자 |