MARC보기
LDR02093nmm uu200397 4500
001000000332376
00520240805170700
008181129s2018 |||||||||||||||||c||eng d
020 ▼a 9780438033986
035 ▼a (MiAaPQ)AAI10784783
035 ▼a (MiAaPQ)unc:17561
040 ▼a MiAaPQ ▼c MiAaPQ ▼d 248032
0820 ▼a 543
1001 ▼a Boyce, Matthew William.
24510 ▼a Developing Tools for Paper-based Cultures to Interrogate Oxygen's Role in Cancer Progression.
260 ▼a [S.l.] : ▼b The University of North Carolina at Chapel Hill., ▼c 2018
260 1 ▼a Ann Arbor : ▼b ProQuest Dissertations & Theses, ▼c 2018
300 ▼a 153 p.
500 ▼a Source: Dissertation Abstracts International, Volume: 79-10(E), Section: B.
500 ▼a Advisers: Matthew R. Lockett
5021 ▼a Thesis (Ph.D.)--The University of North Carolina at Chapel Hill, 2018.
520 ▼a Oxygen plays a direct role in controlling cellular phenotype and invasiveness through hypoxia-inducible transcription factors. These factors, which induce signaling pathways under low-oxygen tensions (i.e., hypoxia), are involved with the mainte
520 ▼a Paper-based cultures are an emerging platform capable of generating thick, tissue-like constructs of cells by simply stacking together cell-laden paper scaffolds. Controlling the diffusion of medium into these cultures results in the formation o
520 ▼a In this work, PBCs were used to explore the relationship between oxygen gradients and cancer chemosensitivity. Quantification of oxygen gradients within PBCs was performed using luminescent oxygen-sensors. Development and characterization of the
590 ▼a School code: 0153.
650 4 ▼a Analytical chemistry.
690 ▼a 0486
71020 ▼a The University of North Carolina at Chapel Hill. ▼b Chemistry.
7730 ▼t Dissertation Abstracts International ▼g 79-10B(E).
773 ▼t Dissertation Abstract International
790 ▼a 0153
791 ▼a Ph.D.
792 ▼a 2018
793 ▼a English
85640 ▼u http://www.riss.kr/pdu/ddodLink.do?id=T14997284 ▼n KERIS
980 ▼a 201812 ▼f 2019
990 ▼a 관리자