| LDR | | 02198nmm uu200433 4500 |
| 001 | | 000000332257 |
| 005 | | 20240805170454 |
| 008 | | 181129s2018 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780355803310 |
| 035 | |
▼a (MiAaPQ)AAI10751306 |
| 035 | |
▼a (MiAaPQ)ucla:16597 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 082 | 0 |
▼a 574 |
| 100 | 1 |
▼a Shimada, Eriko Christine. |
| 245 | 10 |
▼a Many Facets of PNPase - Uncovering the Role of PNPase in the Mitochondria. |
| 260 | |
▼a [S.l.] :
▼b University of California, Los Angeles.,
▼c 2018 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2018 |
| 300 | |
▼a 150 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-08(E), Section: B. |
| 500 | |
▼a Adviser: Michael A. Teitell. |
| 502 | 1 |
▼a Thesis (Ph.D.)--University of California, Los Angeles, 2018. |
| 506 | |
▼a This item is not available from ProQuest Dissertations & Theses. |
| 520 | |
▼a PNPase is a conserved 3'-5' exoribonuclease localized in the mammalian mitochondria. Its expression is essential for embryonic development and mitochondrial homeostasis. PNPase has been recently implicated in regulating mitochondrial RNA import. |
| 520 | |
▼a In order to further study the role of PNPase, we attempted to create a knockout cell line by adjusting the culture conditions to allow cells to survive without functional mitochondria. Interestingly, the resulting cell lines did not have any mit |
| 520 | |
▼a Finally, we characterized endogenous RNA targets of PNPase, its effect on steady state levels of mitochondrial RNA when PNPase expression is knocked down, and its interaction partners. We find that PNPase binds all mitochondrial tRNAs, mRNAs and |
| 590 | |
▼a School code: 0031. |
| 650 | 4 |
▼a Molecular biology. |
| 650 | 4 |
▼a Developmental biology. |
| 690 | |
▼a 0307 |
| 690 | |
▼a 0758 |
| 710 | 20 |
▼a University of California, Los Angeles.
▼b Molecular Biology 0573. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-08B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0031 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T14997164
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자 |