| LDR | | 02269nmm uu200445 4500 |
| 001 | | 000000332178 |
| 005 | | 20240805170206 |
| 008 | | 181129s2018 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438269569 |
| 035 | |
▼a (MiAaPQ)AAI10957215 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 082 | 0 |
▼a 616.079 |
| 100 | 1 |
▼a Yockey, Laura Jeannette. |
| 245 | 10 |
▼a Innate Immune Responses in Zika Virus Control and Pathogenesis. |
| 260 | |
▼a [S.l.] :
▼b Yale University.,
▼c 2018 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2018 |
| 300 | |
▼a 200 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B. |
| 500 | |
▼a Adviser: Akiko Iwasaki. |
| 502 | 1 |
▼a Thesis (Ph.D.)--Yale University, 2018. |
| 520 | |
▼a The female reproductive tract is an important site of viral exposure, in the case of sexually-transmitted infections. It must also protect and support normal pregnancy and development of the fetus, a process that requires complex immunological c |
| 520 | |
▼a First, we developed a mouse model of intravaginal ZIKV infection in order to investigate the innate immune control and pathogenesis of sexually-transmitted ZIKV. Epidemiological data demonstrate that ZIKV can be transmitted between sexual partne |
| 520 | |
▼a Next, we investigate the in vivo role for one of the candidate entry receptors for ZIKV, Axl. Identifying the cellular entry receptor for ZIKV is a critical step towards understanding the unique pathogenesis and tropism of ZIKV as a teratogenic |
| 520 | |
▼a Finally, we investigated how the IFN response of the fetus and fetal-derived placenta contributes to ZIKV-mediated pathology. This question has important implications for understanding the underlying pathogenesis and shared presentation of many |
| 590 | |
▼a School code: 0265. |
| 650 | 4 |
▼a Immunology. |
| 650 | 4 |
▼a Virology. |
| 650 | 4 |
▼a Obstetrics. |
| 690 | |
▼a 0982 |
| 690 | |
▼a 0720 |
| 690 | |
▼a 0380 |
| 710 | 20 |
▼a Yale University. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-12B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0265 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T15001243
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자 |