LDR | | 02230nmm uu200421 4500 |
001 | | 000000332174 |
005 | | 20240805170201 |
008 | | 181129s2018 |||||||||||||||||c||eng d |
020 | |
▼a 9780438269507 |
035 | |
▼a (MiAaPQ)AAI10957209 |
040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
082 | 0 |
▼a 574 |
100 | 1 |
▼a Williams, Danielle Marie. |
245 | 10 |
▼a Engineering protein-based biomaterials using SpyTag/SpyCatcher technology. |
260 | |
▼a [S.l.] :
▼b Yale University.,
▼c 2018 |
260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2018 |
300 | |
▼a 125 p. |
500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B. |
500 | |
▼a Adviser: Lynne Regan. |
502 | 1 |
▼a Thesis (Ph.D.)--Yale University, 2018. |
520 | |
▼a The ability to create linkages using SpyTag/SpyCatcher technology is a powerful tool for protein design and engineering. SpyTag, a 13-residue peptide, and SpyCatcher, a small protein, interact spontaneously to form a covalent isopeptide bond, wh |
520 | |
▼a One such project involves the design of stimulus-responsive hydrogels made entirely of protein components. We took advantage of the modular nature of TPR domains, which bind C-terminal peptides, to interact with cognate peptide cross-linkers to |
520 | |
▼a Other projects described in this text involve the development of geometric protein arrays. Such arrays have implications in signal amplification, biosensing, and enzyme scaffolding array. Using the modular, rod-like protein SasG and SpyTag/SpyCa |
520 | |
▼a Finally, we were able to functionalize 2D surfaces and microcapsules using SpyTag/SpyCatcher technology and a unique, amphiphilic bacterial hydrophobin, Bs1A. Bs1A self-assembles into a stable monolayer at both air-water and water-oil interfaces |
590 | |
▼a School code: 0265. |
650 | 4 |
▼a Biochemistry. |
650 | 4 |
▼a Biophysics. |
690 | |
▼a 0487 |
690 | |
▼a 0786 |
710 | 20 |
▼a Yale University. |
773 | 0 |
▼t Dissertation Abstracts International
▼g 79-12B(E). |
773 | |
▼t Dissertation Abstract International |
790 | |
▼a 0265 |
791 | |
▼a Ph.D. |
792 | |
▼a 2018 |
793 | |
▼a English |
856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T15001240
▼n KERIS |
980 | |
▼a 201812
▼f 2019 |
990 | |
▼a 관리자 |