| LDR | | 02289nmm uu200421 4500 |
| 001 | | 000000332173 |
| 005 | | 20240805170159 |
| 008 | | 181129s2018 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438269422 |
| 035 | |
▼a (MiAaPQ)AAI10957201 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 082 | 0 |
▼a 574.191 |
| 100 | 1 |
▼a Virrueta, Alejandro. |
| 245 | 10 |
▼a Predicting side-chain dihedral angles of protein cores and beyond: An exploration of the limits of the hard-sphere model. |
| 260 | |
▼a [S.l.] :
▼b Yale University.,
▼c 2018 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2018 |
| 300 | |
▼a 130 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B. |
| 500 | |
▼a Adviser: Corey S. O'Hern. |
| 502 | 1 |
▼a Thesis (Ph.D.)--Yale University, 2018. |
| 520 | |
▼a Existing computational approaches for protein structure modeling and prediction typically involve a multi-term potential energy function, more commonly referred to as a 'force field'. These force fields typically model various physical phenomena |
| 520 | |
▼a To address this problem, my dissertation examines the extent to which a simplified energy function that includes only stereochemical constraints and repulsive hard-sphere interactions can correctly predict side-chain dihedral angles of amino aci |
| 520 | |
▼a This dissertation presents three major computational studies. I first examine the hard-sphere predictions of single and multiple repacking of residues in protein cores, and demonstrate that steric interactions are the dominant force in specifyin |
| 520 | |
▼a This work contributes to the forefront of computational protein design by providing an alternate, simplified approach to protein modeling and an understanding of the limitations of the hard-sphere model. With this information, we can gain fundam |
| 590 | |
▼a School code: 0265. |
| 650 | 4 |
▼a Biophysics. |
| 650 | 4 |
▼a Computational physics. |
| 690 | |
▼a 0786 |
| 690 | |
▼a 0216 |
| 710 | 20 |
▼a Yale University. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-12B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0265 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T15001238
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자 |